Trial reportNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2008
The effect of acute tryptophan depletion on the neural correlates of emotional processing in healthy volunteers.
Trial report in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 82 citations in OpenAlex.
- The behavioural effects of the serotonin 1A receptor agonist buspirone on cognition and emotional processing in healthy volunteers.Psychopharmacology · 2025Trial
- Trial
- Effects of acute tryptophan depletion on prefrontal-amygdala connectivity while viewing facial signals of aggression.Biological psychiatry · 2012Trial
- Tryptophan depletion and emotional processing in healthy volunteers at high risk for depression.Biological psychiatry · 2011Trial
- Trial
- The effect of acute tryptophan depletion on emotional distraction and subsequent memory.Social cognitive and affective neuroscience · 2009Trial
- The effects of tryptophan depletion on neural responses to emotional words in remitted depression.Biological psychiatry · 2009Trial
- Acute tryptophan depletion evokes negative mood in healthy females who have previously experienced concurrent negative mood and tryptophan depletion.Psychopharmacology · 2009Trial
- Serotonin transporter genotype and depressive phenotype determination by discriminant analysis of glucose metabolism under acute tryptophan depletion.NeuroImage · 2008Trial
- Direct serotonin release in humans shapes aversive learning and inhibition.Nature communications · 2024Article
- Innate cocaine-seeking vulnerability arising from loss of serotonin-mediated aversive effects of cocaine in rats.Cell reports · 2023Article
- Acute tryptophan depletion alters affective touch perception.Psychopharmacology · 2022Article
- Increasing Central Serotonin with 5-hydroxytryptophan Disrupts the Inhibition of Social Gaze in Nonhuman Primates.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Different depression: motivational anhedonia governs antidepressant efficacy in Huntington's disease.Brain communications · 2022Article
- Visual stimuli induce serotonin release in occipital cortex: A simultaneous positron emission tomography/magnetic resonance imaging study.Human brain mapping · 2020Article
- Differences in how macaques monitor others: Does serotonin play a central role?Wiley interdisciplinary reviews. Cognitive science · 2019Review
- Estrogen, Stress, and Depression: Cognitive and Biological Interactions.Annual review of clinical psychology · 2019Review
- Cognitive Control as a 5-HTFrontiers in psychology · 2019Article
- Depressed mood induction in early cigarette withdrawal is unaffected by acute monoamine precursor supplementation.Neuropsychiatric disease and treatment · 2019Article
- Pons to Posterior Cingulate Functional Projections Predict Affective Processing Changes in the Elderly Following Eight Weeks of Meditation Training.EBioMedicine · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
The processing of affective material is known to be modulated by serotonin (5-HT), but few studies have used neurophysiological measures to characterize the effect of changes in 5-HT on neural responses to emotional stimuli. We used functional magnetic resonance imaging to investigate the effect of acute tryptophan depletion, which reduces central 5-HT synthesis, on neural responses to emotionally valenced verbal stimuli. Though no participants experienced significant mood change, emotional information processing was substantially modified following 5-HT depletion. A behavioral bias toward positive stimuli was attenuated following depletion, which was accompanied by increased hemodynamic responses during the processing of emotional words in several subcortical structures. Inter-individual differences in tryptophan depletion-elicited anxiety correlated positively with the caudate bias toward negative stimuli. These data suggest that 5-HT may play an important role in mediating automatic negative attentional biases in major depression, as well as resilience against negative distracting stimuli in never-depressed individuals.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.