ArticleJournal of human hypertension2008
Sympathoadrenergic and metabolic factors are involved in ambulatory blood pressure rise in childhood obesity.
Article in Journal of human hypertension, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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20 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Update: ambulatory blood pressure monitoring in children and adolescents: a scientific statement from the American Heart Association.Hypertension (Dallas, Tex. : 1979) · 2014Guideline
- The Secretome of Parental and Bone Metastatic Breast Cancer Elicits Distinct Effects in Human Osteoclast Activity after Activation of β2 Adrenergic Signaling.Biomolecules · 2023Article
- School-based surveillance on visit-to-visit blood pressure variability and high blood pressure in children and adolescents.BMC cardiovascular disorders · 2021Article
- The relationship between body fat ratio and blood pressure in school-age children.Journal of human hypertension · 2020Article
- Association between nocturnal blood pressure dipping and insulin resistance in children affected by NAFLD.European journal of pediatrics · 2014Article
- Obese children and adolescents have elevated nighttime blood pressure independent of insulin resistance and arterial stiffness.American journal of hypertension · 2014Article
- Autonomic nervous system dysregulation in pediatric hypertension.Current hypertension reports · 2014Review
- Heart rate and the cardiometabolic risk.Current hypertension reports · 2013Review
- Chemoreceptors, baroreceptors, and autonomic deregulation in children with obstructive sleep apnea.Respiratory physiology & neurobiology · 2013Review
- A novel approach to the study of pediatric obesity: a biomarker model.Pediatric annals · 2012Review
- Impact of obesity on childhood kidney.Pediatric reports · 2011Article
- Insulin resistance in young, lean male subjects with essential hypertension.Journal of human hypertension · 2011Article
- Relationship between cardiovascular risk factors and adipokines in adolescents.Hormone research in paediatrics · 2011Article
- Association of polycystic ovary syndrome and a non-dipping blood pressure pattern in young women.Clinics (Sao Paulo, Brazil) · 2010Article
- Assessing secular trends in blood pressure in children and adolescents.Journal of human hypertension · 2009Article
- Canonical transient receptor potential channels expression is elevated in a porcine model of metabolic syndrome.Molecular endocrinology (Baltimore, Md.) · 2009Article
- Ambulatory blood pressure monitoring in childhood and adult obesity.Current hypertension reports · 2009Review
- Disturbed circadian blood pressure rhythm and C-reactive protein in essential hypertension.Journal of human hypertension · 2008Article
- Sympathoadrenergic and metabolic factors and ambulatory blood pressure changes in childhood obesity.Journal of human hypertension · 2008Article
- Autonomic nervous system: an integrative regulator in circadian rhythm of blood pressure.Frontiers in neurologyReview
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated in a young Italian obese population, the relationship between ambulatory BP (ABP) and several pathophysiological factors linking obesity to hypertension. A total of 89 obese children and adolescents underwent a 24-h ambulatory BP monitoring (ABPM) and an oral glucose tolerance test. The circulating levels of insulin, lipids, uric acid, C-reactive protein, interleukin-6, renin and aldosterone and the 24-h urinary levels of epinephrine, norepinephrine and albumin excretion rate were measured. Nine percent of subjects had daytime sustained hypertension (SH), 26% night-time hypertension and 11% a non-dipping pattern. SH subjects compared to those with sustained normotension (SN) were more obese (P<0.05), with a more frequent family history of hypertension (P<0.05), higher urinary catecholamine (P<0.05) and heart rate values (P<0.05) after adjustment for standard deviation score (SDS) of body mass index (BMI) and sex. Subjects with night-time hypertension compared to those with night-time normotension were more obese (P<0.0001), with a higher prevalence of impaired glucose tolerance (P<0.05) and metabolic syndrome (P<0.05) and higher 2-h glucose (P<0.05), uric acid (P<0.05) and triglycerides (P<0.05). In multivariate regression analysis, daytime systolic BP (SBP) remained independently correlated with urinary norepinephrine and SDS-BMI (P<0.05 for both), daytime diastolic BP (DBP) with waist circumference (P<0.05) and night-time SBP and DBP with SDS-BMI (P<0.01 for both). The risk of having systolic and diastolic hypertension increased with the increase in SDS-BMI and waist circumference, respectively. In conclusion, in our cohort of obese children and adolescents, daytime and night-time hypertension were associated with activation of the sympathoadrenal system and worst metabolic conditions, respectively.
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