ArticleProceedings of the National Academy of Sciences of the United States of America2007
Control of Emi2 activity and stability through Mos-mediated recruitment of PP2A.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 52 citations in OpenAlex.
- Greatwall depletion from Xenopus oocytes reveals a key role of the cyclin B/CDK1-PP2A-B55 balance in the coordination of meiotic events.Nature communications · 2026Article
- Structural mechanism for inhibition of PP2A-B56α and oncogenicity by CIP2A.Nature communications · 2023Article
- EMI2 expression as a poor prognostic factor in patients with breast cancer.The Kaohsiung journal of medical sciences · 2020Article
- Calcineurin promotes APC/C activation at meiotic exit by acting on both XErp1 and Cdc20.EMBO reports · 2018Article
- Vertebrate Reproduction.Cold Spring Harbor perspectives in biology · 2015Review
- Protein phosphatase 2A promotes the transition to G0 during terminal differentiation in Drosophila.Development (Cambridge, England) · 2015Article
- Dual-mode regulation of the APC/C by CDK1 and MAPK controls meiosis I progression and fidelity.The Journal of cell biology · 2014Article
- Suppression of DNA-damage checkpoint signaling by Rsk-mediated phosphorylation of Mre11.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- A genome-wide survey of maternal and embryonic transcripts during Xenopus tropicalis development.BMC genomics · 2013Article
- Release from meiotic arrest in ascidian eggs requires the activity of two phosphatases but not CaMKII.Development (Cambridge, England) · 2013Article
- Modulation of cell cycle control during oocyte-to-embryo transitions.The EMBO journal · 2013Review
- Pioneering the Xenopus oocyte and egg extract system.The Journal of biological chemistry · 2012Article
- Regulation of the action of early mitotic inhibitor 1 on the anaphase-promoting complex/cyclosome by cyclin-dependent kinases.The Journal of biological chemistry · 2011Article
- Non-proteolytic ubiquitylation counteracts the APC/C-inhibitory function of XErp1.EMBO reports · 2011Article
- Essential role of protein phosphatase 2A in metaphase II arrest and activation of mouse eggs shown by okadaic acid, dominant negative protein phosphatase 2A, and FTY720.The Journal of biological chemistry · 2011Article
- Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases.Microbiology and molecular biology reviews : MMBR · 2011Review
- Canonical and Alternative Pathways in Cyclin-Dependent Kinase 1/Cyclin B Inactivation upon M-Phase Exit in Xenopus laevis Cell-Free Extracts.Enzyme research · 2011Article
- Mos in the oocyte: how to use MAPK independently of growth factors and transcription to control meiotic divisions.Journal of signal transduction · 2011Article
- Mouse Emi2 as a distinctive regulatory hub in second meiotic metaphase.Development (Cambridge, England) · 2010Article
- Emi2-mediated inhibition of E2-substrate ubiquitin transfer by the anaphase-promoting complex/cyclosome through a D-box-independent mechanism.Molecular biology of the cell · 2010Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
Before fertilization, vertebrate eggs are arrested in meiosis II by cytostatic factor (CSF), which holds the anaphase-promoting complex (APC) in an inactive state. It was recently reported that Mos, an integral component of CSF, acts in part by promoting the Rsk-mediated phosphorylation of the APC inhibitor Emi2/Erp1. We report here that Rsk phosphorylation of Emi2 promotes its interaction with the protein phosphatase PP2A. Emi2 residues adjacent to the Rsk phosphorylation site were important for PP2A binding. An Emi2 mutant that retained Rsk phosphorylation but lacked PP2A binding could not be modulated by Mos. PP2A bound to Emi2 acted on two distinct clusters of sites phosphorylated by Cdc2, one responsible for modulating its stability during CSF arrest and one that controls binding to the APC. These findings provide a molecular mechanism for Mos action in promoting CSF arrest and also define an unusual mechanism, whereby protein phosphorylation recruits a phosphatase for dephosphorylation of distinct sites phosphorylated by another kinase.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.