ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
Genetic disruption of protein kinase A anchoring reveals a role for compartmentalized kinase signaling in theta-burst long-term potentiation and spatial memory.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 50 citations in OpenAlex.
- Synaptic Mechanisms of Delay Eyeblink Classical Conditioning: AMPAR Trafficking and Gene Regulation in an In Vitro Model.Molecular neurobiology · 2023Review
- Mice Lacking the cAMP Effector Protein POPDC1 Show Enhanced Hippocampal Synaptic Plasticity.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Selective role of the translin/trax RNase complex in hippocampal synaptic plasticity.Molecular brain · 2020Article
- Induction of β-adrenergic metaplasticity of LTP requires intact anchoring of PKA.Learning & memory (Cold Spring Harbor, N.Y.) · 2019Article
- Noradrenergic stabilization of heterosynaptic LTP requires activation of Epac in the hippocampus.Learning & memory (Cold Spring Harbor, N.Y.) · 2019Article
- Repeated shock stress facilitates basolateral amygdala synaptic plasticity through decreased cAMP-specific phosphodiesterase type IV (PDE4) expression.Brain structure & function · 2018Article
- Cell-Specific PKM Isoforms Contribute to the Maintenance of Different Forms of Persistent Long-Term Synaptic Plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Two rare AKAP9 variants are associated with Alzheimer's disease in African Americans.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2014Article
- A presynaptic role for PKA in synaptic tagging and memory.Neurobiology of learning and memory · 2014Article
- Sequential delivery of synaptic GluA1- and GluA4-containing AMPA receptors (AMPARs) by SAP97 anchored protein complexes in classical conditioning.The Journal of biological chemistry · 2014Article
- Sensitivity to theta-burst timing permits LTP in dorsal striatal adult brain slice.Journal of neurophysiology · 2013Article
- AKAPs integrate genetic findings for autism spectrum disorders.Translational psychiatry · 2013Article
- Gravin orchestrates protein kinase A and β2-adrenergic receptor signaling critical for synaptic plasticity and memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Subcellular location of PKA controls striatal plasticity: stochastic simulations in spiny dendrites.PLoS computational biology · 2012Article
- AKAP signaling complexes in regulation of excitatory synaptic plasticity.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2011Review
- Colocalization of protein kinase A with adenylyl cyclase enhances protein kinase A activity during induction of long-lasting long-term-potentiation.PLoS computational biology · 2011Article
- AKAP signaling in reinstated cocaine seeking revealed by iTRAQ proteomic analysis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- AKAP79/150 impacts intrinsic excitability of hippocampal neurons through phospho-regulation of A-type K+ channel trafficking.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Brain region-specific decrease in the activity and expression of protein kinase A in the frontal cortex of regressive autism.PloS one · 2011Article
- Mutations in AKAP5 disrupt dendritic signaling complexes and lead to electrophysiological and behavioral phenotypes in mice.PloS one · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Studies of hippocampal long-term potentiation (LTP), a cellular model of memory storage, implicate cAMP-dependent protein kinase (PKA) in presynaptic and postsynaptic mechanisms of LTP. The anchoring of PKA to AKAPs (A kinase-anchoring proteins) creates compartmentalized pools of PKA, but the roles of presynaptically and postsynaptically anchored forms of PKA in late-phase LTP are unclear. In this study, we have created genetically modified mice that conditionally express Ht31, an inhibitor of PKA anchoring, to probe the roles of anchored PKA in hippocampal LTP and spatial memory. Our findings show that at hippocampal Schaffer collateral CA3-CA1 synapses, theta-burst LTP requires presynaptically anchored PKA. In addition, a pool of anchored PKA in hippocampal area CA3 is required for spatial memory. These findings reveal a novel and significant role for anchored PKA signaling in cellular mechanisms underlying memory storage.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.