ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
Interkinetic nuclear migration and the selection of neurogenic cell divisions during vertebrate retinogenesis.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers.
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Who cites it
96 citing papers in PubMed, 182 citations in OpenAlex.
- Cytoplasmic localization of the mRNA encoding actin regulator, Serendipity-bioRxiv : the preprint server for biology · 2025Article
- Glycolytic flux controls retinal progenitor cell differentiation via regulating Wnt signaling.eLife · 2025Article
- Molecular mechanisms controlling vertebrate retinal patterning, neurogenesis, and cell fate specification.Trends in genetics : TIG · 2023Review
- Common and divergent gene regulatory networks control injury-induced and developmental neurogenesis in zebrafish retina.Research square · 2023Article
- Synchronisation of apical constriction and cell cycle progression is a conserved behaviour of pseudostratified neuroepithelia informed by their tissue geometry.Developmental biology · 2023Article
- LATS1/2 control TGFB-directed epithelial-to-mesenchymal transition in the murine dorsal cranial neuroepithelium through YAP regulation.Development (Cambridge, England) · 2022Article
- Brain Organization and Human Diseases.Cells · 2022Review
- UHRF2 regulates cell cycle, epigenetics and gene expression to control the timing of retinal progenitor and ganglion cell differentiation.Development (Cambridge, England) · 2022Article
- Retina organoids: Window into the biophysics of neuronal systems.Biophysics reviews · 2022Review
- Timing and Distribution of Mitotic Activity in the Retina During Precocial and Altricial Modes of Avian Development.Frontiers in neuroscience · 2022Article
- A single-cell guide to retinal development: Cell fate decisions of multipotent retinal progenitors in scRNA-seq.Developmental biology · 2021Review
- Development and maintenance of vision's first synapse.Developmental biology · 2021Review
- Cytoskeletal control of early mammalian development.Nature reviews. Molecular cell biology · 2021Review
- The role of cell lineage in the development of neuronal circuitry and function.Developmental biology · 2021Review
- 4-Dimensional Imaging of Zebrafish Optic Cup Morphogenesis.Journal of visualized experiments : JoVE · 2021Article
- Autosomal Recessive Primary Microcephaly: Not Just a Small Brain.Frontiers in cell and developmental biology · 2021Review
- Laminin β2 Chain Regulates Cell Cycle Dynamics in the Developing Retina.Frontiers in cell and developmental biology · 2021Article
- Asymmetric neurogenic commitment of retinal progenitors involves Notch through the endocytic pathway.eLife · 2020Article
- Nuclear crowding and nonlinear diffusion during interkinetic nuclear migration in the zebrafish retina.eLife · 2020Article
- Dynamic Polarization of Rab11a Modulates Crb2a Localization and Impacts Signaling to Regulate Retinal Neurogenesis.Frontiers in cell and developmental biology · 2020Article
36 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
During retinal development, neuroepithelial progenitor cells divide in either a symmetric proliferative mode, in which both daughter cells remain mitotic, or in a neurogenic mode, in which at least one daughter cell exits the cell cycle and differentiates as a neuron. Although the cellular mechanisms of neurogenesis remain unknown, heterogeneity in cell behaviors has been postulated to influence this cell fate. In this study, we analyze interkinetic nuclear migration, the apical-basal movement of nuclei in phase with the cell cycle, and the relationship of this cell behavior to neurogenesis. Using time-lapse imaging in zebrafish, we show that various parameters of interkinetic nuclear migration are significantly heterogeneous among retinal neuroepithelial cells. We provide direct evidence that neurogenic progenitors have greater basal nuclei migrations during the last cell cycle preceding a terminal mitosis. In addition, we show that atypical protein kinase C (aPKC)-mediated cell polarity is essential for the relationship between nuclear position and neurogenesis. Loss of aPKC also resulted in increased proliferative cell divisions and reduced retinal neurogenesis. Our data support a novel model for neurogenesis, in which interkinetic nuclear migration differentially positions nuclei in neuroepithelial cells and therefore influences selection of progenitors for cell cycle exit based on apical-basal polarized signals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.