ReviewBiochimica et biophysica acta2008
Peptide-based fluorescent sensors of protein kinase activity: design and applications.
Review in Biochimica et biophysica acta, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- A Constellation of Fluorescent Biosensors to Illuminate the Galaxy of Protein Kinases.Chembiochem : a European journal of chemical biology · 2026Review
- Embracing enzyme promiscuity with activity-based compressed biosensing.Cell reports methods · 2023Article
- Shining Light on Protein Kinase Biomarkers with Fluorescent Peptide Biosensors.Life (Basel, Switzerland) · 2022Review
- Electrochemical Peptide-Based Sensors for Foodborne Pathogens Detection.Molecules (Basel, Switzerland) · 2021Review
- Kinase Signaling in Dendritic Development and Disease.Frontiers in cellular neuroscience · 2021Review
- A simple, robust, universal assay for real-time enzyme monitoring by signalling changes in nucleoside phosphate anion concentration using a europium(iii)-based anion receptor.Chemical science · 2019Article
- Visualization of Compartmentalized Kinase Activity Dynamics Using Adaptable BimKARs.Chemistry & biology · 2015Article
- Fluorescent Reporters and Biosensors for Probing the Dynamic Behavior of Protein Kinases.Proteomes · 2015Review
- Quantification of protein kinase enzymatic activity in unfractionated cell lysates using CSox-based sensors.Current protocols in chemical biology · 2014Article
- Probing enzymatic activity inside living cells using a nanowire-cell "sandwich" assay.Nano letters · 2013Article
- Photocleavable peptide-oligonucleotide conjugates for protein kinase assays by MALDI-TOF MS.Molecular bioSystems · 2012Article
- A fluorescent reporter of the phosphorylation status of the substrate protein STAT3.Angewandte Chemie (International ed. in English) · 2011Article
- Measuring enzyme activity in single cells.Trends in biotechnology · 2011Review
- Fluorescent peptide biosensor for probing the relative abundance of cyclin-dependent kinases in living cells.PloS one · 2011Article
- Visualizing tyrosine kinase activity with bipartite tetracysteine display.Chembiochem : a European journal of chemical biology · 2010Article
- Development of pH-responsive fluorescent false neurotransmitters.Journal of the American Chemical Society · 2010Article
- New strategies for fluorescent probe design in medical diagnostic imaging.Chemical reviews · 2010Review
- The chemical biology of protein phosphorylation.Annual review of biochemistry · 2009Review
- Uber-responsive peptide-based sensors of signaling proteins.Angewandte Chemie (International ed. in English) · 2009Article
- Monitoring protein kinases in cellular media with highly selective chimeric reporters.Angewandte Chemie (International ed. in English) · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Protein kinases control the flow of information through cell-signaling pathways. A detailed analysis of their behavior enhances our ability to understand normal cellular states and to devise therapeutic interventions for diseases. The design and application of "Environmentally-Sensitive", "Deep-Quench" and "Self-Reporting" sensor systems for studying protein kinase activity are described. These sensors allow real-time activity measurements in a continuous manner for a wide variety of kinases. As these sensors can be adapted from an in vitro screen to imaging kinase activity in living cells, they support both preliminary and later stages of drug discovery.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.