ArticlePLoS biology2007
Chromatin structure regulates gene conversion.
Article in PLoS biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 45 citations in OpenAlex.
- Unique chicken B cell development: species-specific mechanisms and contradictory requirements of B cell receptor for post-hatched B cell development.Frontiers in immunology · 2026Review
- Molecular mechanisms of avian immunoglobulin gene diversification and prospect for industrial applications.Frontiers in immunology · 2024Review
- Article
- Somatic Diversification of Rearranged Antibody Gene Segments by Intra- and Interchromosomal Templated Mutagenesis.Journal of immunology (Baltimore, Md. : 1950) · 2022Article
- Genome Fractionation and Loss of Heterozygosity in Hybrids and Polyploids: Mechanisms, Consequences for Selection, and Link to Gene Function.Molecular biology and evolution · 2021Article
- TET3 dioxygenase modulates gene conversion at the avian immunoglobulin variable region via demethylation of non-CpG sites in pseudogene templates.Genes to cells : devoted to molecular & cellular mechanisms · 2021Article
- What Can Long Terminal Repeats Tell Us About the Age of LTR Retrotransposons, Gene Conversion and Ectopic Recombination?Frontiers in plant science · 2020Article
- Review
- The Tumor-Associated Variant RAD51 G151D Induces a Hyper-Recombination Phenotype.PLoS genetics · 2016Article
- The histone acetyltransferase component TRRAP is targeted for destruction during the cell cycle.Oncogene · 2014Article
- A role for reactive oxygen species in JAK2 V617F myeloproliferative neoplasm progression.Leukemia · 2013Article
- FANCJ couples replication past natural fork barriers with maintenance of chromatin structure.The Journal of cell biology · 2013Article
- JAK2 and genomic instability in the myeloproliferative neoplasms: a case of the chicken or the egg?American journal of hematology · 2012Review
- Epigenetic modification of the repair donor regulates targeted gene correction.Molecular therapy. Nucleic acids · 2012Article
- Antigenic variation and the generation of diversity in malaria parasites.Current opinion in microbiology · 2012Review
- JAK2(V617F) negatively regulates p53 stabilization by enhancing MDM2 via La expression in myeloproliferative neoplasms.Oncogene · 2012Article
- Article
- Dynamics of homology searching during gene conversion in Saccharomyces cerevisiae revealed by donor competition.Genetics · 2011Article
- Article
- Recurring mutations in myeloproliferative neoplasms alter epigenetic regulation of gene expression.American journal of cancer research · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Homology-directed repair is a powerful mechanism for maintaining and altering genomic structure. We asked how chromatin structure contributes to the use of homologous sequences as donors for repair using the chicken B cell line DT40 as a model. In DT40, immunoglobulin genes undergo regulated sequence diversification by gene conversion templated by pseudogene donors. We found that the immunoglobulin Vlambda pseudogene array is characterized by histone modifications associated with active chromatin. We directly demonstrated the importance of chromatin structure for gene conversion, using a regulatable experimental system in which the heterochromatin protein HP1 (Drosophila melanogaster Su[var]205), expressed as a fusion to Escherichia coli lactose repressor, is tethered to polymerized lactose operators integrated within the pseudo-Vlambda donor array. Tethered HP1 diminished histone acetylation within the pseudo-Vlambda array, and altered the outcome of Vlambda diversification, so that nontemplated mutations rather than templated mutations predominated. Thus, chromatin structure regulates homology-directed repair. These results suggest that histone modifications may contribute to maintaining genomic stability by preventing recombination between repetitive sequences.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.