ArticleObesity surgery2007
An obese rat model of bariatric surgery with gastric banding.
Article in Obesity surgery, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Meal patterns after bariatric surgery in mice and rats.Appetite · 2020Review
- Effects of sleeve gastrectomy and gastric banding on the hypothalamic feeding center in an obese rat model.Surgery today · 2015Article
- Effects of sleeve gastrectomy on lipid metabolism in an obese diabetic rat model.Obesity surgery · 2013Article
- A comparative study of gastric banding and sleeve gastrectomy in an obese diabetic rat model.Obesity surgery · 2011Article
- Animal models in bariatric surgery--a review of the surgical techniques and postsurgical physiology.Obesity surgery · 2010Review
- Additional effect of visceral fat resection in an obese rat model of gastric banding.Obesity surgery · 2009Article
- Rat models for bariatric surgery and surgery for type 2 diabetes mellitus.Obesity surgery · 2009Review
- A rodent model of adjustable gastric band surgery-implications for the understanding of underlying mechanisms.Obesity surgery · 2009Article
- The original experimental model in rats to study gastric banding surgery.Obesity surgery · 2008Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBariatric surgery is the only treatment that can provide effective long-term weight loss for morbid obesity. However, animal models of bariatric surgery have not yet been well established. The aims of this study were to establish an obese rat model of gastric banding and to determine whether the model would replicate the procedure of human gastric banding in terms of weight loss and metabolic parameters.
methods27 male Zucker fatty rats were divided into 3 groups: the sham-operated control, gastric banding, and diet treatment groups. They were followed for 8 weeks after surgery, and their body weight change, cumulative food intake and metabolic parameters were examined.
resultsFor the sham-operated control, gastric banding, and diet treatment groups, the mean body weights were 644 +/- 28 g, 511 +/- 77 g, and 339 +/- 15 g; % change of weight at 8 weeks after operaion were +63.7 +/- 8.3%, +33.2 +/- 20%, -12.0 +/- 2.0%, respectively. Absolute weekly food intake amounts were 233.8 +/- 38.1 g, 157.3 +/- 64 g, 80 g, and cumulative food intakes were 1862 +/- 111 g, 1258 +/- 375 g and 640 g, respectively. The gastric banding rats showed significant decreases in weight gain, % change of weight, absolute weekly food intake, and cumulative food intake compared to sham-operated control rats (P < 0.05). The banding group also had lower levels of all metabolic parameters compared with controls (P < 0.01), and these levels were equal to those of the diet-treated group.
conclusionThe present study provides a new animal model of gastric banding using obese rats. This model may be useful in research on the biochemical and molecular mechanisms of morbid obesity.
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