ArticleNaunyn-Schmiedeberg's archives of pharmacology2007
Stress-induced release of substance P in the locus coeruleus modulates cortical noradrenaline release.
Article in Naunyn-Schmiedeberg's archives of pharmacology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- The role of neuropeptides in suicidal behavior: a systematic review.BioMed research international · 2013Pooled it
- Neurokinin-1-receptor antagonism decreases anxiety and emotional arousal circuit response to noxious visceral distension in women with irritable bowel syndrome: a pilot study.Alimentary pharmacology & therapeutics · 2012Trial
- A Chemically Stable Photocaged Noradrenaline.ACS chemical neuroscience · 2025Article
- Vicarious defeat stress induces increased alcohol consumption in female mice: Role of neurokinin-1 receptor and interleukin-6.Addiction biology · 2024Article
- A Hypothalamic-Controlled Neural Reflex Promotes Corneal Inflammation.Investigative ophthalmology & visual science · 2021Article
- Article
- Effect of the fragrance inhalation of essential oil from Asarum heterotropoides on depression-like behaviors in mice.BMC complementary and alternative medicine · 2015Article
- The behavioural response of mice lacking NK₁ receptors to guanfacine resembles its clinical profile in treatment of ADHD.British journal of pharmacology · 2014Article
- Substance P exacerbates dopaminergic neurodegeneration through neurokinin-1 receptor-independent activation of microglial NADPH oxidase.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Activation of NK₁ receptors in the locus coeruleus induces analgesia through noradrenergic-mediated descending inhibition in a rat model of neuropathic pain.British journal of pharmacology · 2012Article
- Cortical nNOS neurons co-express the NK1 receptor and are depolarized by Substance P in multiple mammalian species.Frontiers in neural circuits · 2012Article
- Physiology of quantal norepinephrine release from somatodendritic sites of neurons in locus coeruleus.Frontiers in molecular neuroscience · 2012Article
- Translational and reverse translational research on the role of stress in drug craving and relapse.Psychopharmacology · 2011Review
- A mouse model of high trait anxiety shows reduced heart rate variability that can be reversed by anxiolytic drug treatment.The international journal of neuropsychopharmacology · 2011Article
- Translating the neuroscience of alcoholism into clinical treatments: from blocking the buzz to curing the blues.Neuroscience and biobehavioral reviews · 2010Review
- Neurokinin-1 receptors (NK1R:s), alcohol consumption, and alcohol reward in mice.Psychopharmacology · 2010Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several lines of evidence implicate the neuropeptide substance P (SP) in the modulation of emotional behavior. Interaction between SP and noradrenergic systems has been proposed to be important in the regulation of stress, depression, and anxiety mechanisms; however, most evidence so far is based on studies in unchallenged and/or anesthetized animals. Thus, by using a dual-probe microdialysis approach in freely moving animals, the aim of the present study was to investigate whether a relevant stressor can trigger the release of SP in the locus coeruleus (LC) and whether and how this response modulates noradrenaline (NA) transmission both in the LC and in the medial prefrontal cortex (mPFC), an important LC terminal region involved in emotional processing. While confirming previous reports that neurokinin 1 receptor (NK1R) antagonists activate cortical noradrenergic transmission under resting conditions, we present evidence that this interaction is opposite during stress challenge. Our results show that exposure to forced swimming considerably enhanced the release of SP and NA in the LC. Administration of a selective NK1R antagonist into the LC potentiated this NA response within the LC but abolished the stress-induced increase in NA release within the mPFC. These findings demonstrate stress-induced increase in endogenous extracellular SP levels within the LC exerting a facilitatory effect on the noradrenergic pathway to the mPFC. The attenuation of stress-induced hyperactivation of this pathway by NK1R antagonists, presumably via enhancing NA and autoinhibition in the LC, may contribute to the therapeutic efficacy of these drugs known to ameliorate symptoms of stress-related disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.