ArticlePloS one2007
Persistent infection and promiscuous recombination of multiple genotypes of an RNA virus within a single host generate extensive diversity.
Article in PloS one, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 53 citations in OpenAlex.
- Intra-Host Citrus Tristeza Virus Populations during Prolonged Infection Initiated by a Well-Defined Sequence Variant inViruses · 2024Article
- Discovery of a Closterovirus Infecting Jujube Plants Grown at Aksu Area in Xinjiang of China.Viruses · 2023Article
- Detection of Plant Viruses and Disease Management: Relevance of Genetic Diversity and Evolution.Frontiers in plant science · 2020Review
- Variations of five eIF4E genes across cassava accessions exhibiting tolerant and susceptible responses to cassava brown streak disease.PloS one · 2017Article
- Article
- Widespread recombination, reassortment, and transmission of unbalanced compound viral genotypes in natural arenavirus infections.PLoS pathogens · 2015Article
- Genetic diversity and molecular evolution of Plum bark necrosis stem pitting-associated virus from China.PloS one · 2014Article
- Genetic variability and evolutionary dynamics of viruses of the family Closteroviridae.Frontiers in microbiology · 2013Article
- Developing an understanding of cross-protection by Citrus tristeza virus.Frontiers in microbiology · 2013Article
- Citrus tristeza virus: Evolution of Complex and Varied Genotypic Groups.Frontiers in microbiology · 2013Article
- The defective RNAs of Closteroviridae.Frontiers in microbiology · 2013Article
- High codon adaptation in citrus tristeza virus to its citrus host.Virology journal · 2012Article
- Genetic diversity and evidence for recent modular recombination in Hawaiian Citrus tristeza virus.Virus genes · 2010Article
- Infection with strains of Citrus tristeza virus does not exclude superinfection by other strains of the virus.Journal of virology · 2010Article
- The pathogenicity determinant of Citrus tristeza virus causing the seedling yellows syndrome maps at the 3'-terminal region of the viral genome.Molecular plant pathology · 2010Article
- Populations of genomic RNAs devoted to the replication or spread of a bipartite plant virus differ in genetic structure.Journal of virology · 2009Article
- Genetic variation and recombination of RdRp and HSP 70h genes of Citrus tristeza virus isolates from orange trees showing symptoms of citrus sudden death disease.Virology journal · 2008Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recombination and reassortment of viral genomes are major processes contributing to the creation of new, emerging viruses. These processes are especially significant in long-term persistent infections where multiple viral genotypes co-replicate in a single host, generating abundant genotypic variants, some of which may possess novel host-colonizing and pathogenicity traits. In some plants, successive vegetative propagation of infected tissues and introduction of new genotypes of a virus by vector transmission allows for viral populations to increase in complexity for hundreds of years allowing co-replication and subsequent recombination of the multiple viral genotypes. Using a resequencing microarray, we examined a persistent infection by a Citrus tristeza virus (CTV) complex in citrus, a vegetatively propagated, globally important fruit crop, and found that the complex comprised three major and a number of minor genotypes. Subsequent deep sequencing analysis of the viral population confirmed the presence of the three major CTV genotypes and, in addition, revealed that the minor genotypes consisted of an extraordinarily large number of genetic variants generated by promiscuous recombination between the major genotypes. Further analysis provided evidence that some of the recombinants underwent subsequent divergence, further increasing the genotypic complexity. These data demonstrate that persistent infection of multiple viral genotypes within a host organism is sufficient to drive the large-scale production of viral genetic variants that may evolve into new and emerging viruses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.