ArticleProceedings of the National Academy of Sciences of the United States of America2007
Species-specific positive selection of the male-specific lethal complex that participates in dosage compensation in Drosophila.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 57 citations in OpenAlex.
- The long reach of the Red Queen.Nature reviews. Genetics · 2026Article
- Rapid compensatory evolution within a multiprotein complex preserves telomere integrity.Science (New York, N.Y.) · 2025Article
- Aberrant X chromosome dosage compensation causes hybrid male inviability inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- A noncanonical role of roX RNAs in autosomal epigenetic repression.Nature communications · 2025Article
- Recent Advances and Future Potential of Long Non-Coding RNAs in Insects.International journal of molecular sciences · 2023Review
- Spatiotemporal Regulation of a Single Adaptively Evolving Trans-Regulatory Element Contributes to Spermatogenetic Expression Divergence in Drosophila.Molecular biology and evolution · 2022Article
- A single synonymous nucleotide change impacts the male-killing phenotype of prophage WO geneeLife · 2021Article
- Hybrid Sterility, Genetic Conflict and Complex Speciation: Lessons From theFrontiers in genetics · 2021Review
- Rapid Evolution of Autosomal Binding Sites of the Dosage Compensation Complex inFrontiers in genetics · 2021Article
- Adaptive evolution of an essential telomere protein restricts telomeric retrotransposons.eLife · 2020Article
- The Effect of Hybridization on Dosage Compensation in Member Species of the Anopheles gambiae Species Complex.Genome biology and evolution · 2018Article
- Common and unique strategies of male killing evolved in two distinctProceedings. Biological sciences · 2018Article
- GFZF, a GlutathioneMolecular and cellular biology · 2018Article
- Article
- Male-killing symbiont damages host's dosage-compensated sex chromosome to induce embryonic apoptosis.Nature communications · 2016Article
- Expansion of GA Dinucleotide Repeats Increases the Density of CLAMP Binding Sites on the X-Chromosome to Promote Drosophila Dosage Compensation.PLoS genetics · 2016Article
- Molecular Evolution of Drosophila Germline Stem Cell and Neural Stem Cell Regulating Genes.Genome biology and evolution · 2015Article
- A screen for F1 hybrid male rescue reveals no major-effect hybrid lethality loci in the Drosophila melanogaster autosomal genome.G3 (Bethesda, Md.) · 2014Article
- Recurrent turnover of chromosome-specific satellites in Drosophila.Genome biology and evolution · 2014Article
- Conservation and de novo acquisition of dosage compensation on newly evolved sex chromosomes in Drosophila.Genes & development · 2013Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
In many taxa, males and females have unequal ratios of sex chromosomes to autosomes, which has resulted in the invention of diverse mechanisms to equilibrate gene expression between the sexes (dosage compensation). Failure to compensate for sex chromosome dosage results in male lethality in Drosophila. In Drosophila, a male-specific lethal (MSL) complex of proteins and noncoding RNAs binds to hundreds of sites on the single male X chromosome and up-regulates gene expression. Here we use population genetics of two closely related Drosophila species to show that adaptive evolution has occurred in all five protein-coding genes of the MSL complex. This positive selection is asymmetric between closely related species, with a very strong signature apparent in Drosophila melanogaster but not in Drosophila simulans. In particular, the MSL1 and MSL2 proteins have undergone dramatic positive selection in D. melanogaster, in domains previously shown to be responsible for their specific targeting to the X chromosome. This signature of positive selection at an essential protein-DNA interface of the complex is unexpected and suggests that X chromosomal MSL-binding DNA segments may themselves be changing rapidly. This highly asymmetric, rapid evolution of the MSL genes further suggests that misregulated dosage compensation may represent one of the underlying causes of male hybrid inviability in Drosophila, wherein the fate of hybrid males depends on which species' X chromosome is inherited.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.