ArticleInternational journal of experimental pathology2007
BALB/c mice resistant to Toxoplasma gondii infection proved to be highly susceptible when previously infected with Myocoptes musculinus fur mites.
Article in International journal of experimental pathology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- The role of IL-12 in stimulating NK cells against Toxoplasma gondii infection: a mini-review.Parasitology research · 2021Review
- Mite Burden and Immunophenotypic Response toComparative medicine · 2020Article
- Ectoparasite Burden, Clinical Disease, and Immune Responses throughout Fur Mite (Myocoptes musculinus) Infestation in C57BL/6 and Rag1(-/-) Mice.Comparative medicine · 2016Article
- Combined evaluation of commonly used techniques, including PCR, for diagnosis of mouse fur mites.Journal of the American Association for Laboratory Animal Science : JAALAS · 2014Article
- Effect of sampling strategy on the detection of fur mites within a naturally infested colony of mice (Mus musculus).Journal of the American Association for Laboratory Animal Science : JAALAS · 2011Article
- Soiled bedding sentinels for the detection of fur mites in mice.Journal of the American Association for Laboratory Animal Science : JAALAS · 2011Article
- Assessment of immune activation in mice before and after eradication of mite infestation.Journal of the American Association for Laboratory Animal Science : JAALAS · 2009Article
- Neurological and behavioral abnormalities, ventricular dilatation, altered cellular functions, inflammation, and neuronal injury in brains of mice due to common, persistent, parasitic infection.Journal of neuroinflammation · 2008Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The immune response induced by Toxoplasma gondii is characterized by Th1 immune mechanisms. We previously demonstrated that C57BL/6 mice infested with Myocoptes musculinus and infected with T. gondii by intraperitoneal route undergo accelerated mortality according to Th2 immune mechanisms induced by the acarian. To evaluate whether infection with M. musculinus influences T. gondii-induced Th1 response in a resistant mouse lineage, BALB/c, which develops latent chronic toxoplasmosis in a way similar to that observed in immunocompetent humans, this study was done. The animals were infected with T. gondii ME-49 strain 1 month after M. musculinus infestation, being the survival and the immune response monitored. The double-infected displayed higher mortality rate if compared with the mono-infected mice. In addition, infection with M. musculinus changed the T. gondii-specific immune response, converting BALB/c host to a susceptible phenotype. Spleen cells had increased the levels of IL-4 in double-infected mice. This alteration was associated with severe pneumonia, encephalitis and wasting condition. In addition, a higher tissue parasitism was observed in double-infected animals. It can be concluded that infection with these two contrasting parasites, M. musculinus and T. gondii, may convert an immunocompetent host into a susceptible one, and such a host will develop severe toxoplasmosis.
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