ArticleThe journal of physical chemistry. B2007
Vibrational stark effect probes for nucleic acids.
Article in The journal of physical chemistry. B, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Eyes on the Prize: Tracking Electron Transfer in G-Rich Duplex and Quadruplex DNA Using Enantiopure Ruthenium Polypyridyl Infrared Redox Probes.Journal of the American Chemical Society · 2025Article
- Visualizing partial solvation at the air-water interface.Chemical science · 2024Article
- Good Vibrations Report on the DNA Quadruplex Binding of an Excited State Amplified Ruthenium Polypyridyl IR Probe.Journal of the American Chemical Society · 2023Article
- Vibrational Spectroscopy of Phytochromes.Biomolecules · 2023Review
- Nitrile Infrared Intensities Characterize Electric Fields and Hydrogen Bonding in Protic, Aprotic, and Protein Environments.Journal of the American Chemical Society · 2022Article
- Extending the vibrational lifetime of azides with heavy atoms.Physical chemistry chemical physics : PCCP · 2020Article
- A Critical Evaluation of Vibrational Stark Effect (VSE) Probes with the Local Vibrational Mode Theory.Sensors (Basel, Switzerland) · 2020Article
- Two-Dimensional Infrared Study of Vibrational Coupling between Azide and Nitrile Reporters in a RNA Nucleoside.The journal of physical chemistry. B · 2016Article
- Measurement of the membrane dipole electric field in DMPC vesicles using vibrational shifts of p-cyanophenylalanine and molecular dynamics simulations.The journal of physical chemistry. B · 2015Article
- Multicolor live-cell chemical imaging by isotopically edited alkyne vibrational palette.Journal of the American Chemical Society · 2014Article
- Solvent-induced infrared frequency shifts in aromatic nitriles are quantitatively described by the vibrational Stark effect.The journal of physical chemistry. B · 2012Article
- Site-Specific Spectroscopic Reporters of the Local Electric Field, Hydration, Structure, and Dynamics of Biomolecules.The journal of physical chemistry letters · 2011Article
- Modulating Accidental Fermi Resonance: What a Difference a Neutron Makes.The journal of physical chemistry letters · 2011Article
- A direct comparison of azide and nitrile vibrational probes.Physical chemistry chemical physics : PCCP · 2011Article
- 2D IR photon echo of azido-probes for biomolecular dynamics.Physical chemistry chemical physics : PCCP · 2011Article
- 5-Cyanotryptophan as an Infrared Probe of Local Hydration Status of Proteins.Chemical physics letters · 2009Article
- FTIR analysis of GPCR activation using azido probes.Nature chemical biology · 2009Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The vibrational Stark effect (VSE) has proven to be an effective method for the study of electric fields in proteins via the use of infrared probes. To explore the use of VSE in nucleic acids, we investigated the Stark spectroscopy of nine structurally diverse nucleosides. These nucleosides contained nitrile or azide probes in positions that correspond to both the major and minor grooves of DNA. The nitrile probes showed better characteristics and exhibited absorption frequencies over a broad range; that is, from 2253 cm-1 for 2'-O-cyanoethyl ribonucleosides 8 and 9 to 2102 cm(-1) for a 13C-labeled 5-thiocyanatomethyl-2'-deoxyuridine 3c. The largest Stark tuning rate observed was |Deltamu| = 1.1 cm(-1)/(MV/cm) for both 5-cyano-2'-deoxyuridine 1 and N2-nitrile-2'-deoxyguanosine 7. The latter is a particularly attractive probe because of its high extinction coefficient (epsilon = 412 M-1cm-1) and ease of incorporation into oligomers.
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Registered trials
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