ArticleBiochemistry2007
Human SWI/SNF drives sequence-directed repositioning of nucleosomes on C-myc promoter DNA minicircles.
Article in Biochemistry, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Altered nucleosome positions in maize haplotypes and mutants of a subset of SWI/SNF-like proteins.Plant direct · 2017Article
- NEK1 kinase domain structure and its dynamic protein interactome after exposure to Cisplatin.Scientific reports · 2017Article
- Review
- Fulvestrant induces resistance by modulating GPER and CDK6 expression: implication of methyltransferases, deacetylases and the hSWI/SNF chromatin remodelling complex.British journal of cancer · 2013Article
- Nucleosome sliding mechanisms: new twists in a looped history.Nature structural & molecular biology · 2013Review
- Disparity in the DNA translocase domains of SWI/SNF and ISW2.Nucleic acids research · 2012Article
- SWI/SNF chromatin remodeling complex: a new cofactor in reprogramming.Stem cell reviews and reports · 2012Review
- Multiple distinct stimuli increase measured nucleosome occupancy around human promoters.PloS one · 2011Article
- Divergent human remodeling complexes remove nucleosomes from strong positioning sequences.Nucleic acids research · 2010Article
- Predicting nucleosome positions on the DNA: combining intrinsic sequence preferences and remodeler activities.Nucleic acids research · 2009Article
- Analysis of individual remodeled nucleosomes reveals decreased histone-DNA contacts created by hSWI/SNF.Nucleic acids research · 2009Article
- Chromatin remodelers act globally, sequence positions nucleosomes locally.Journal of molecular biology · 2009Article
- Multiple aspects of ATP-dependent nucleosome translocation by RSC and Mi-2 are directed by the underlying DNA sequence.PloS one · 2009Article
- Human SWI/SNF directs sequence-specific chromatin changes on promoter polynucleosomes.Nucleic acids research · 2008Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The human SWI/SNF (hSWI/SNF) ATP-dependent chromatin remodeling complex is a tumor suppressor and essential transcriptional coregulator. SWI/SNF complexes have been shown to alter nucleosome positions, and this activity is likely to be important for their functions. However, previous studies have largely been unable to determine the extent to which DNA sequence might control nucleosome repositioning by SWI/SNF complexes. Here, we employ a minicircle remodeling approach to provide the first evidence that hSWI/SNF moves nucleosomes in a sequence dependent manner, away from nucleosome positioning sequences favored during nucleosome assembly. This repositioning is unaffected by the presence of DNA nicks, and can occur on closed-circular DNAs in the absence of topoisomerases. We observed directed nucleosome movement on minicircles derived from the human SWI/SNF-regulated c-myc promoter, which may contribute to the previously observed "disruption" of two promoter nucleosomes during c-myc activation in vivo. Our results suggest a model wherein hSWI/SNF-directed nucleosome movement away from default positioning sequences results in sequence-specific regulatory effects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.