ArticleWorld journal of gastroenterology2007
Expression of periostin and its clinicopathological relevance in gastric cancer.
Article in World journal of gastroenterology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 37 citations in OpenAlex.
- Evolving tumor microenvironment: Driving cancer initiation and progression in cardiovascular diseases.iScience · 2025Review
- Targeted inhibition of Ninjurin2 promotes chemosensitivity in chemoresistant gastric cancer by suppressing cancer-initiating cells.Biomarker research · 2025Article
- Periostin: biology and function in cancer.Cancer cell international · 2022Review
- Tumor- and Osteoblast-Derived Periostin in Prostate Cancer bone Metastases.Frontiers in oncology · 2021Article
- Heterogeneous Periostin Expression in Different Histological Variants of Papillary Thyroid Carcinoma.BioMed research international · 2017Article
- Role of periostin in esophageal, gastric and colon cancer.Oncology letters · 2016Article
- Isoprenaline Induces Periostin Expression in Gastric Cancer.Yonsei medical journal · 2016Article
- Role of periostin and its antagonist PNDA-3 in gastric cancer metastasis.World journal of gastroenterology · 2015Review
- Upregulation of periostin prevents P53-mediated apoptosis in SGC-7901 gastric cancer cells.Molecular biology reports · 2013Article
- Periostin directly and indirectly promotes tumor lymphangiogenesis of head and neck cancer.PloS one · 2012Article
- Periostin expression and epithelial-mesenchymal transition in cancer: a review and an update.Virchows Archiv : an international journal of pathology · 2011Review
- Quantitative glycoproteomic analysis of optimal cutting temperature-embedded frozen tissues identifying glycoproteins associated with aggressive prostate cancer.Analytical chemistry · 2011Article
- Relevance of periostin splice variants in renal cell carcinoma.The American journal of pathology · 2011Article
- Enhanced proliferation, invasion, and epithelial-mesenchymal transition of nicotine-promoted gastric cancer by periostin.World journal of gastroenterology · 2011Article
- Article
- The multifaceted role of periostin in tumorigenesis.Cellular and molecular life sciences : CMLS · 2009Review
- Periostin and bone marrow fibrosis.International journal of hematology · 2008Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the expression and localization of periostin in gastric cancer and its clinical relevance.
methodsReverse transcriptase polymerase chain reaction was used to measure periostin mRNA expression. Western blotting was carried out to detect periostin protein expression. Immunohistochemistry was performed to localize and quantify the expression of periostin in benign gastric diseases and gastric cancer, and immunostaining results were correlated with gastric cancer pathological stages.
resultsPeriostin expression was low at both mRNA and protein levels in normal gastric tissues, but was overexpressed in gastric cancer tissues. Immunohistochemical staining revealed that periostin was overexpressed in primary gastric cancer, as well as in metastatic lymph nodes, but only faint staining was found in benign gastric ulcers. By quantitative analysis of the immunostaining results, periostin expression was increased 2.5-4-fold in gastric cancer, compared to that in benign gastric disease, and there was a trend toward increasing periostin expression with tumor stage.
conclusionThis observation demonstrated that periostin was overexpressed in gastric cancer and lymph node metastasis, which suggests that periostin plays an important role in the progression and metastasis of gastric cancer.
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