ArticleWorld journal of gastroenterology2007
Lead exposure increases oxidative stress in the gastric mucosa of HCl/ethanol-exposed rats.
Article in World journal of gastroenterology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 116 citations in OpenAlex.
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- Oxidative stress responses as a marker of toxicity in mice exposed to polluted groundwater from an automobile junk market in South-Western Nigeria.Cell stress & chaperones · 2022Article
- Lead Toxicity From a Swallowed Fishing Sinker: A Case Report.JPGN reports · 2021Article
- Nephroprotective effect of methanol extract ofAfrican health sciences · 2020Article
- Disruption of cytochrome P450 enzymes in the liver and small intestine in chicken embryos in ovo exposed to glyphosate.Environmental science and pollution research international · 2020Article
- Evaluation of the Acute Hepatoprotective Potential of Hydroethanolic Extract ofJournal of toxicology · 2020Article
- Effect of cocoa powder on hypertension and antioxidant status in uninephrectomized hypertensive rats.Veterinary world · 2019Article
- Kolaviron attenuated arsenic acid induced-cardiorenal dysfunction via regulation of ROS, C-reactive proteins (CRP), cardiac troponin I (CTnI) and BCL2.Journal of traditional and complementary medicine · 2018Article
- Oxidative stress changes observed in selected organs of African giant rats (International journal of veterinary science and medicine · 2018Article
- Sodium arsenite-induced cardiovascular and renal dysfunction in rat via oxidative stress and protein kinase B (Akt/PKB) signaling pathway.Redox report : communications in free radical research · 2017Article
- Effect of arsenic acid withdrawal on hepatotoxicity and disruption of erythrocyte antioxidant defense system.Toxicology reports · 2017Article
- Mitigation of diazinon-induced cardiovascular and renal dysfunction by gallic acid.Interdisciplinary toxicology · 2016Article
- Antioxidant and gastric cytoprotective prostaglandins properties of Cassia sieberiana roots bark extract as an anti-ulcerogenic agent.BMC complementary and alternative medicine · 2012Article
- Cardiovascular and renal oxidative stress-mediated toxicities associated with bisphenol-A exposures are mitigated byAvicenna journal of phytomedicineArticle
- Naringin mitigates testicular injury and associated neuronal toxicity in lead-exposed cockerel chicks.Avicenna journal of phytomedicineArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the role of reactive oxygen species in the ulcer-aggravating effect of lead in albino rats.
methodsAlbino Wistar rats were randomly divided into three groups and treated orally with 100 mg/L (low dose) or 5000 mg/L (high dose) of lead acetate for 15 wk. A third group received saline and served as control. At the end of wk 15, colorimetric assays were applied to determine the concentrations of total protein and nitrite, the activities of the oxidative enzymes catalase and superoxide dismutase, and lipid peroxidation in homogenized gastric mucosal samples.
resultsExposure of rats to lead significantly increased the gastric mucosal damage caused by acidified ethanol. Although the basal gastric acid secretory rate was not significantly altered, the maximal response of the stomach to histamine was significantly higher in the lead-exposed animals than in the unexposed control group. Exposure to low and high levels of lead significantly increased gastric lipid peroxidation to 183.2%+/-12.7% and 226.1%+/-6.8% of control values respectively (P<0.0). On the other hand, lead exposure significantly decreased catalase and superoxide dismutase (SOD) activities and the amount of nitrite in gastric mucosal samples.
conclusionLead increases the formation of gastric ulcers by interfering with the oxidative metabolism in the stomach.
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