ArticleClinical oral investigations2008
Gingival levels of monocyte chemoattractant protein-1 (MCP-1) in diabetes mellitus and periodontitis: an experimental study in rats.
Article in Clinical oral investigations, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 28 citations in OpenAlex.
- Effect of Danzhijiangtang capsule on monocyte chemoattractant protein-1 mRNA expression in newly diagnosed diabetes subclinical vascular lesions.World journal of gastroenterology · 2013Trial
- Co-culture of bone marrow stem cells and macrophages indicates intermediate mechanism between local inflammation and innate immune system in diabetic periodontitis.Experimental and therapeutic medicine · 2016Article
- Dietary arginine silicate inositol complex inhibits periodontal tissue loss in rats with ligature-induced periodontitis.Drug design, development and therapy · 2016Article
- Diabetes as a risk factor for medication-related osteonecrosis of the jaw.Journal of dental research · 2015Review
- Relationship of clinical and microbiological variables in patients with type 1 diabetes mellitus and periodontitis.Medical science monitor : international medical journal of experimental and clinical research · 2014Article
- Serum levels of inflammatory markers in type 2 diabetes patients with chronic periodontitis.Journal of applied oral science : revista FOB · 2014Article
- Molecular mechanisms involved in the bidirectional relationship between diabetes mellitus and periodontal disease.Journal of Indian Society of Periodontology · 2013Review
- Variation of serum monocyte chemoattractant protein-1 in patients with diabetes and metabolic syndrome.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2011Article
- The influence of diabetes mellitus on periodontal tissues: a pilot study.Journal of periodontal & implant science · 2010Article
- Estimation of the salivary levels of monocyte chemoattractant protein-1 and macrophage inflammatory protein-1α in periodontitis patients with and without diabetes in comparison to systemically and periodontally healthy individuals.Journal of Indian Society of PeriodontologyArticle
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objectives of this study were to investigate and compare the monocyte chemoattractant protein-1 (MCP-1) levels of gingival tissues in diabetes mellitus (DM) and periodontitis and to reveal the effects of MCP-1 on periodontal inflammation and destruction in these diseases. DM was created in 15 rats (group 1) by streptozotocin injection, and periodontitis was obtained by ligature induction in 15 rats (group 2). Fifteen systemically and periodontally healthy rats were used as control (group 3). Gingival MCP-1 levels were measured by enzyme-linked immunosorbent assay (ELISA). Periodontal inflammation was quantified by the inflammatory cell infiltration in the gingival samples, whereas periodontal destruction was assessed by the alveolar bone loss in the experimental regions. MCP-1 concentrations were higher in groups 1 and 2 than in group 3 (p < 0.001). Increased gingival inflammatory cell infiltration and alveolar bone loss were observed in groups 1 and 2 compared to group 3 (p < 0.001). There were positive correlations among the MCP-1 level, gingival inflammatory cell infiltration, and alveolar bone loss in groups 1 and 2 (p < 0.001). Our results suggest that (1) DM may lead to enhanced MCP-1 production in periodontal tissues likewise for periodontitis and (2) there may be a positive correlation between the MCP-1 concentration and diseased nature of periodontium in both diseases.
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