Evidence map›Paper›PMID 17876001›Full record

ArticleAntimicrobial agents and chemotherapy2007

Intrinsic novobiocin resistance in Staphylococcus saprophyticus.

Anna A Vickers, Ian Chopra, Alex J O'Neill

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 40 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. In Vitro Effects ofInternational journal of microbiology · 2026
    Article
  5. Article
  6. Characteristics ofInternational journal of molecular sciences · 2025
    Article
  7. Genomic and phenotypic characterization of Chryseomicrobium imtechense from canine pyometra.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025
    Article
  8. Article
  9. Antibiotics (Basel, Switzerland) · 2021
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Anna A VickersAntimicrobial Research Centre and Research Institute of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom.
Ian Chopra
Alex J O'Neill
University of Leeds · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intrinsic novobiocin resistance in Staphylococcus saprophyticus was associated with expression of a novobiocin-resistant form of the drug target protein (GyrB). Site-directed mutagenesis established that resistance depends upon the presence of two specific amino acid residues in GyrB: a glycine at position 85 and a lysine at position 140.

Indexed as

Amino Acid SequenceAmino Acid SubstitutionAnti-Bacterial AgentsDNA GyraseDrug Resistance, BacterialMicrobial Sensitivity TestsMolecular Sequence DataMutagenesis, Site-DirectedNovobiocinSequence Homology, Amino AcidStaphylococcusAnti-Bacterial AgentsDNA GyraseNovobiocin

Identifiers

PMID17876001
PMCPMC2167987
OpenAlexW2111445694

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.