ArticleMolecular and cellular biology2007
SOS2 promotes salt tolerance in part by interacting with the vacuolar H+-ATPase and upregulating its transport activity.
Article in Molecular and cellular biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 112 papers.
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112 citing papers in PubMed, 257 citations in OpenAlex.
- SOT2/Growth-Regulating Factor 3 Modulates Salt Tolerance by Regulating Gibberellin-DELLA Signalling.Plant, cell & environment · 2026Article
- The architecture of salt tolerance: A multi-scale view of sodium transport in plants.Plant communications · 2026Review
- Integrating morphophysiological traits with salt-responsive gene expression uncovers cultivar-specific tolerance mechanisms in faba beans facing NaCl stress.Scientific reports · 2026Article
- Root-Specific Signal Modules Mediating Abiotic Stress Tolerance in Fruit Crops.Plants (Basel, Switzerland) · 2026Review
- Comparative proteomic analysis of Tunisian barley landraces in response to salinity at the tillering stage.Protoplasma · 2026Article
- Advances in deciphering the mechanisms of salt tolerance in Maize.Plant signaling & behavior · 2025Review
- Detection of Cytosolic Ion Concentrations by the Trans-Golgi Network/Early Endosome is Important for Salt Tolerance.bioRxiv : the preprint server for biology · 2025Article
- Multi-locus genome-wide association studies reveal genomic regions associated with sodicity tolerance in rice.Plant molecular biology · 2025Article
- Enhancing Soybean Salt Tolerance with GSNO and Silicon: A Comprehensive Physiological, Biochemical, and Genetic Study.International journal of molecular sciences · 2025Article
- Genome-wide identification, characterization, and functional analysis of the CHX, SOS, and RLK genes in Solanum lycopersicum under salt stress.Scientific reports · 2025Article
- Integrated physiological and transcriptomic analysis reveals the key pathways ofFrontiers in plant science · 2025Article
- Physiological and differential protein expression analyses of the calcium stress response in theHeliyon · 2024Article
- Deciphering the genetic basis of salinity tolerance in a diverse panel of cultivated and wild soybean accessions by genome-wide association mapping.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- Whole Genome Duplication Events Likely Contributed to the Aquatic Adaptive Evolution of Parkerioideae.Plants (Basel, Switzerland) · 2024Article
- Comparative transcriptome analysis reveals the adaptive mechanisms of halophyteFrontiers in plant science · 2024Article
- Mitochondrial alternative oxidase pathway helps in nitrooxidative stress tolerance in germinating chickpea.Journal of biosciences · 2024Article
- The proteome landscape of the root cap reveals a role for the jacalin-associated lectin JAL10 in the salt-induced endoplasmic reticulum stress pathway.Plant communications · 2023Article
- Genome assembly and genetic dissection of a prominent drought-resistant maize germplasm.Nature genetics · 2023Article
- Structural and Functional Diversity of Two ATP-Driven Plant Proton Pumps.International journal of molecular sciences · 2023Review
- Genome wide identification of GDSL gene family explores a novel GhirGDSL26 gene enhancing drought stress tolerance in cotton.BMC plant biology · 2023Article
52 more citing papers are in PubMed but not listed here.
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9 authors at 3 institutions in 2 countries.
Funding
Abstract
The salt overly sensitive (SOS) pathway is critical for plant salt stress tolerance and has a key role in regulating ion transport under salt stress. To further investigate salt tolerance factors regulated by the SOS pathway, we expressed an N-terminal fusion of the improved tandem affinity purification tag to SOS2 (NTAP-SOS2) in sos2-2 mutant plants. Expression of NTAP-SOS2 rescued the salt tolerance defect of sos2-2 plants, indicating that the fusion protein was functional in vivo. Tandem affinity purification of NTAP-SOS2-containing protein complexes and subsequent liquid chromatography-tandem mass spectrometry analysis indicated that subunits A, B, C, E, and G of the peripheral cytoplasmic domain of the vacuolar H+-ATPase (V-ATPase) were present in a SOS2-containing protein complex. Parallel purification of samples from control and salt-stressed NTAP-SOS2/sos2-2 plants demonstrated that each of these V-ATPase subunits was more abundant in NTAP-SOS2 complexes isolated from salt-stressed plants, suggesting that the interaction may be enhanced by salt stress. Yeast two-hybrid analysis showed that SOS2 interacted directly with V-ATPase regulatory subunits B1 and B2. The importance of the SOS2 interaction with the V-ATPase was shown at the cellular level by reduced H+ transport activity of tonoplast vesicles isolated from sos2-2 cells relative to vesicles from wild-type cells. In addition, seedlings of the det3 mutant, which has reduced V-ATPase activity, were found to be severely salt sensitive. Our results suggest that regulation of V-ATPase activity is an additional key function of SOS2 in coordinating changes in ion transport during salt stress and in promoting salt tolerance.
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