ArticleMolecular and cellular biology2007
Identification of phosphotyrosine binding domain-containing proteins as novel downstream targets of the EphA8 signaling function.
Article in Molecular and cellular biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Hunting for Novel Routes in Anticancer Drug Discovery: Peptides against Sam-Sam Interactions.International journal of molecular sciences · 2022Review
- The molecular dynamics of subdistal appendages in multi-ciliated cells.Nature communications · 2021Article
- Regulation of proline-directed kinases and the trans-histone code H3K9me3/H4K20me3 during human myogenesis.The Journal of biological chemistry · 2019Article
- Ependymal Cells Require Anks1a for Their Proper Development.Molecules and cells · 2019Article
- Anks1a regulates COPII-mediated anterograde transport of receptor tyrosine kinases critical for tumorigenesis.Nature communications · 2016Article
- Patient Mutations of the Intellectual Disability Gene KDM5C Downregulate Netrin G2 and Suppress Neurite Growth in Neuro2a Cells.Journal of molecular neuroscience : MN · 2016Article
- In Vivo Expression of the PTB-deleted Odin Mutant Results in Hydrocephalus.Molecules and cells · 2015Article
- EphA receptors form a complex with caspase-8 to induce apoptotic cell death.Molecules and cells · 2015Article
- Eph receptor and ephrin function in breast, gut, and skin epithelia.Cell adhesion & migration · 2014Review
- Mechanisms of ephrin receptor protein kinase-independent signaling in amphid axon guidance in Caenorhabditis elegans.Genetics · 2013Article
- EphrinA5-EphA7 complex induces apoptotic cell death via TNFR1.Molecules and cells · 2013Article
- Article
- RINL, guanine nucleotide exchange factor Rab5-subfamily, is involved in the EphA8-degradation pathway with odin.PloS one · 2012Article
- Endocytosis of EphA receptors is essential for the proper development of the retinocollicular topographic map.The EMBO journal · 2011Article
- The interactome of a PTB domain-containing adapter protein, Odin, revealed by SILAC.Journal of proteomics · 2011Article
- The SAM domains of Anks family proteins are critically involved in modulating the degradation of EphA receptors.Molecular and cellular biology · 2010Article
- Odin (ANKS1A) is a Src family kinase target in colorectal cancer cells.Cell communication and signaling : CCS · 2008Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Eph receptors and ephrins have been implicated in a variety of cellular processes, including morphology and motility, because of their ability to modulate intricate signaling networks. Here we show that the phosphotyrosine binding (PTB) domain-containing proteins AIDA-1b and Odin are tightly associated with the EphA8 receptor in response to ligand stimulation. Both AIDA-1b and Odin belong to the ankyrin repeat and sterile alpha motif domain-containing (Anks) protein family. The PTB domain of Anks family proteins is crucial for their association with the juxtamembrane domain of EphA8, whereas EphA8 tyrosine kinase activity is not required for this protein-protein interaction. In addition, we found that Odin is a more physiologically relevant partner of EphA8 in mammalian cells. Interestingly, overexpression of the Odin PTB domain alone attenuated EphA8-mediated inhibition of cell migration in HEK293 cells, suggesting that it acts as a dominant-negative mutant of the endogenous Odin protein. More importantly, small interfering RNA-mediated Odin silencing significantly diminished ephrinA5-induced EphA8 signaling effects, which inhibit cell migration in HEK293 cells and retract growing neurites of Neuro2a cells. Taken together, our findings support a possible function for Anks family proteins as scaffolding proteins of the EphA8 signaling pathway.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.