ArticleThe journal of histochemistry and cytochemistry : official journal of the Histochemistry Society2008
Label-retaining cells in the rat submandibular gland.
Article in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 43 citations in OpenAlex.
- Role of quiescent cells in the homeostatic maintenance of the adult submandibular salivary gland.iScience · 2022Article
- Aldehyde dehydrogenase 3A1 deficiency leads to mitochondrial dysfunction and impacts salivary gland stem cell phenotype.PNAS nexus · 2022Article
- Building a Functional Salivary Gland for Cell-Based Therapy: More than Secretory Epithelial Acini.Tissue engineering. Part A · 2020Review
- Concise Review: A Critical Evaluation of Criteria Used to Define Salivary Gland Stem Cells.Stem cells (Dayton, Ohio) · 2019Review
- Diverse progenitor cells preserve salivary gland ductal architecture after radiation-induced damage.Development (Cambridge, England) · 2018Article
- Salivary gland stem cells: A review of development, regeneration and cancer.Genesis (New York, N.Y. : 2000) · 2018Review
- Adult enteric nervous system in health is maintained by a dynamic balance between neuronal apoptosis and neurogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Article
- Salivary Glands: Stem Cells, Self-duplication, or Both?Journal of dental research · 2015Review
- Thyroid hormone responsive protein spot 14 enhances lipogenesis in bovine mammary epithelial cells.In vitro cellular & developmental biology. Animal · 2015Article
- Analysis of histone H2BGFP retention in mouse submandibular gland reveals actively dividing stem cell populations.Stem cells and development · 2015Article
- A population of progenitor cells in the basal and intermediate layers of the murine bladder urothelium contributes to urothelial development and regeneration.Developmental dynamics : an official publication of the American Association of Anatomists · 2014Article
- Label-retaining cells in the adult murine salivary glands possess characteristics of adult progenitor cells.PloS one · 2014Article
- Anatomy and histology of rodent and human major salivary glands: -overview of the Japan salivary gland society-sponsored workshop-.Acta histochemica et cytochemica · 2012Article
- Detection of BrdU-label retaining cells in the lacrimal gland: implications for tissue repair.Cell and tissue research · 2011Article
- TSP-1 promotes glomerular mesangial cell proliferation and extracellular matrix secretion in Thy-1 nephritis rats.Journal of biomedical research · 2011Article
- Lung stem cells--from an evolving understanding to a paradigm shift?Stem cell research & therapy · 2011Article
- Novel stem/progenitor cell population from murine tracheal submucosal gland ducts with multipotent regenerative potential.Stem cells (Dayton, Ohio) · 2011Article
- Ascl3 knockout and cell ablation models reveal complexity of salivary gland maintenance and regeneration.Developmental biology · 2011Article
- Epithelial stem/progenitor cells in the embryonic mouse submandibular gland.Frontiers of oral biology · 2010Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To identify stem cells in salivary glands, label-retaining cells (LRCs) were established in rat submandibular glands. Developing and regenerating glands were labeled with bromodeoxyuridine (BrdU). To cause gland regeneration, the glands were injured by duct obstruction. BrdU LRCs were observed in all the parenchymal structures except for the acinus of the glands labeled during regeneration. Among these LRCs, a few, but not many, expressed neither keratin18 (K18; an acinar/duct cell marker) nor alpha-smooth muscle actin (alphaSMA; a myoepithelial cell marker), and thus were putative stem cells. These (K18 and alphaSMA)(neg) LRCs were invariably observed in the intercalated duct and the excretory duct. In the intercalated duct, they were at the proximal end bordering the acinus (the neck of the intercalated duct). Next, to test the above identification, gland extirpation experiments were performed. LRCs were established by labeling developing glands with iododeoxyuridine (IdU) in place of BrdU. Removal of one submandibular gland forced the IdU-LRCs in the remaining gland to divide. They were labeled with chlorodeoxyuridine (CldU). The (K18 and alphaSMA)(neg) LRCs in the neck of the intercalated duct and in the excretory duct did not change in number or in IdU label. The CldU label appeared in these cells and then disappeared. These results indicate that the (K18 and alphaSMA)(neg) LRCs have divided asymmetrically and are thus considered salivary gland stem cells.
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Registered trials
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