ArticleThe Journal of membrane biology1991
Role of voltage-dependent ionic currents in coupling glucose stimulation to insulin secretion in canine pancreatic islet B-cells.
Article in The Journal of membrane biology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 40 citations in OpenAlex.
- Sodium channels in non-excitable cells: powerful actions and therapeutic targets beyond Hodgkin and Huxley.Trends in cell biology · 2025Review
- Voltage gated sodium channels in cancer and their potential mechanisms of action.Channels (Austin, Tex.) · 2019Article
- Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men.Physiological reviews · 2018Review
- Calcium Channels in Postnatal Development of Rat Pancreatic Beta Cells and Their Role in Insulin Secretion.Frontiers in endocrinology · 2018Article
- High-content screening identifies a role for Na(+) channels in insulin production.Royal Society open science · 2015Article
- Multiparameter screening reveals a role for Na+ channels in cytokine-induced β-cell death.Molecular endocrinology (Baltimore, Md.) · 2014Article
- Maintenance of stimulus-secretion coupling and single beta-cell function in cryopreserved-thawed human islets of Langerhans.Pflugers Archiv : European journal of physiology · 2005Article
- alpha-Latrotoxin increases spontaneous and depolarization-evoked exocytosis from pancreatic islet beta-cells.The Journal of physiology · 2005Article
- Voltage-operated calcium channel heterogeneity in pancreatic beta cells: physiopathological implications.Journal of bioenergetics and biomembranes · 2003Review
- The Ca2+ dynamics of isolated mouse beta-cells and islets: implications for mathematical models.Biophysical journal · 2003Article
- Na+ channel inactivation: a comparative study between pancreatic islet beta-cells and adrenal chromaffin cells in rat.The Journal of physiology · 2003Article
- Voltage-gated and resting membrane currents recorded from B-cells in intact mouse pancreatic islets.The Journal of physiology · 1999Article
- Neurotransmitters and their receptors in the islets of Langerhans of the pancreas: what messages do acetylcholine, glutamate, and GABA transmit?Endocrine · 1998Review
- Characterization of a Ca2+-activated K+ current in insulin-secreting murine betaTC-3 cells.The Journal of physiology · 1998Article
- Alterations in basal and glucose-stimulated voltage-dependent Ca2+ channel activities in pancreatic beta cells of non-insulin-dependent diabetes mellitus GK rats.The Journal of clinical investigation · 1996Article
- Voltage-dependent Na+ and Ca2+ currents in human pancreatic islet beta-cells: evidence for roles in the generation of action potentials and insulin secretion.Pflugers Archiv : European journal of physiology · 1995Article
- cAMP-enhancing agents "permit" stimulus-secretion coupling in canine pancreatic islet beta-cells.The Journal of membrane biology · 1994Article
- Inactivation of voltage-dependent calcium current in an insulinoma cell line.European biophysics journal : EBJ · 1994Article
- Sensitivity to dihydropyridines, omega-conotoxin and noradrenaline reveals multiple high-voltage-activated Ca2+ channels in rat insulinoma and human pancreatic beta-cells.Pflugers Archiv : European journal of physiology · 1993Article
- Role of voltage-dependent ionic currents in coupling glucose stimulation to insulin secretion in canine pancreatic islet B-cells.The Journal of membrane biology · 1991Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Glucose-induced electrical activity in canine pancreatic islet B cells is distinct from that in rodent islets, though both display Ca(2+)-dependent insulin secretion. Rodent islet B cells undergo regular bursts of Ca(2+)-dependent action potentials, while canine islet B cells generate isolated Na(+)-dependent action potentials which often give way to a plateau depolarization. Here we present evidence to reconcile the species difference in electrical activity with the similarity of Ca2+ dependence of secretion. (i) In canine B cells increasing glucose concentrations produce membrane depolarization and increasing frequency of Nao-dependent action potentials until a background membrane potential (approximately -40 mV) is reached where Na+ currents are inactivated. (ii) Voltage-dependent Ca2+ currents are present which are activated over the voltage excursion of the action potential (-50 to +20 mV) and inactivate slowly, (over seconds) in the range of the plateau depolarization (-40 to -25 mV). Hence, they are available to contribute to both phases of depolarization. (iii) Tetrodotoxin (TTX) reduces by half an early transient phase of glucose-stimulated insulin secretion but not a subsequent prolonged plateau phase. The transient phase of secretion often corresponds well in time to the period of initial high frequency action potential activity. These latter results suggest that in canine B cells voltage-dependent Na+ and Ca2+ currents mediate biphasic glucose-induced insulin secretion. The early train of Na(+)-dependent action potentials, by transiently activating Ca2+ channels and allowing pulsatile Ca2+ entry, may promote an early transient phase of insulin secretion. The subsequent sustained plateau depolarization, by allowing sustained Ca2+ entry, may permit steady insulin release.
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