ReviewPflugers Archiv : European journal of physiology2008
Mechano-sensitivity of ENaC: may the (shear) force be with you.
Review in Pflugers Archiv : European journal of physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed.
- The impact of Asic2 deletion on metabolic homeostasis in mice.Physiological reports · 2025Article
- Epithelial NaComprehensive Physiology · 2024Review
- Vascular mechanotransduction.Physiological reviews · 2023Review
- Endothelial Glycocalyx and Cardiomyocyte Damage Is Prevented by Recombinant Syndecan-1 in Acute Myocardial Infarction.The American journal of pathology · 2023Article
- βENaC and ASIC2 associate in VSMCs to mediate pressure-induced constriction in the renal afferent arteriole.American journal of physiology. Renal physiology · 2022Article
- Baroreceptors in the Aortic Arch and Their Potential Role in Aortic Dissection and Aneurysms.Journal of clinical medicine · 2022Review
- Mechanical properties of the premature lung: From tissue deformation under load to mechanosensitivity of alveolar cells.Frontiers in bioengineering and biotechnology · 2022Article
- What Evolutionary Evidence Implies About the Identity of the Mechanoelectrical Couplers in Vascular Smooth Muscle Cells.Physiology (Bethesda, Md.) · 2021Review
- Review
- Shear force sensing of epithelial NaProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Epithelial NaFrontiers in physiology · 2020Article
- A microphysiological model of the bronchial airways reveals the interplay of mechanical and biochemical signals in bronchospasm.Nature biomedical engineering · 2019Article
- Shear force modulates the activity of acid-sensing ion channels at low pH or in the presence of non-proton ligands.Scientific reports · 2019Article
- Increased ENaC activity during kidney preservation in Wisconsin solution.BMC nephrology · 2019Article
- Functional expression of the mechanosensitive PIEZO1 channel in primary endometrial epithelial cells and endometrial organoids.Scientific reports · 2019Article
- Cellular and Molecular Mechanisms Underlying Arterial Baroreceptor Remodeling in Cardiovascular Diseases and Diabetes.Neuroscience bulletin · 2019Review
- Activation of the epithelial sodium channel (ENaC) leads to cytokine profile shift to pro-inflammatory in labor.EMBO molecular medicine · 2018Article
- Plate-based Large-scale Cultivation of Caenorhabditis elegans: Sample Preparation for the Study of Metabolic Alterations in Diabetes.Journal of visualized experiments : JoVE · 2018Article
- The role of stretch-activated ion channels in acute respiratory distress syndrome: finally a new target?American journal of physiology. Lung cellular and molecular physiology · 2016Review
- Altered ENaC is Associated With Aortic Baroreceptor Dysfunction in Chronic Heart Failure.American journal of hypertension · 2016Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The epithelial Na+ channel (ENaC) is the rate-limiting step for Na+ absorption in various vertebrate epithelia and deeply enmeshed in the control of salt and water homeostasis. The phylogenetic relationship of ENaC molecules to mechano-sensitive Degenerins from Caenorhabditis elegans indicates that ENaC might be mechano-sensitive as well. Primarily, it was suggested that ENaC might be activated by membrane stretch. However, this issue still remains to be clarified because controversial results were published. Recent publications indicate that shear stress represents an adequate stimulus, activating ENaC via increasing the single-channel open probability. Basing on the experimental evidence published within the past years and integrating this knowledge into a model related to the mechano-sensitive receptor complex known from C. elegans, we introduce a putative mechanism concerning the mechano-sensitivity of ENaC. We suggest that mechano-sensitive ENaC activation represents a nonhormonal regulatory mechanism. This feature could be of considerable physiological significance because many Na+-absorbing epithelia are exposed to shear forces. Furthermore, it may explain the wide distribution of ENaC proteins in nonepithelial tissues. Nevertheless, it remains a challenge for future studies to explore the mechanism how ENaC is controlled by mechanical forces and shear stress in particular.
Indexed as
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17874325What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.