ArticleEuropean journal of epidemiology2007
Geographic distribution of amyotrophic lateral sclerosis through motor neuron disease mortality data.
Article in European journal of epidemiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 58 citations in OpenAlex.
- Biclustering data analysis: a comprehensive survey.Briefings in bioinformatics · 2024Review
- Focusing on mitochondria in the brain: from biology to therapeutics.Translational neurodegeneration · 2024Review
- Review
- Early-onset, conjugal, twin-discordant, and clusters of sporadic ALS: Pathway to discovery of etiologyFrontiers in neuroscience · 2023Review
- Airborne lead and polychlorinated biphenyls (PCBs) are associated with amyotrophic lateral sclerosis (ALS) risk in the U.S.The Science of the total environment · 2022Article
- Fungal Neurotoxins and Sporadic Amyotrophic Lateral Sclerosis.Neurotoxicity research · 2019Review
- Spatial analyses of ALS incidence in Denmark over three decades.Amyotrophic lateral sclerosis & frontotemporal degeneration · 2018Article
- Vitamin D and Neurological Diseases: An Endocrine View.International journal of molecular sciences · 2017Review
- Potential Environmental Factors in Amyotrophic Lateral Sclerosis.Neurologic clinics · 2015Review
- Geographic Variation of Amyotrophic Lateral Sclerosis Incidence in New Jersey, 2009-2011.American journal of epidemiology · 2015Article
- Searching for a link between the L-BMAA neurotoxin and amyotrophic lateral sclerosis: a study protocol of the French BMAALS programme.BMJ open · 2014Article
- An exploratory spatial analysis of ALS incidence in Ireland over 17.5 years (1995-July 2013).PloS one · 2014Article
- The epidemiology of ALS: a conspiracy of genes, environment and time.Nature reviews. Neurology · 2013Review
- Exposure to lipophilic chemicals as a cause of neurological impairments, neurodevelopmental disorders and neurodegenerative diseases.Interdisciplinary toxicology · 2013Review
- Exploring motor and visual imagery in Amyotrophic Lateral Sclerosis.Experimental brain research · 2013Article
- The relation between amyotrophic lateral sclerosis and inorganic selenium in drinking water: a population-based case-control study.Environmental health : a global access science source · 2010Article
- The cyanobacteria derived toxin Beta-N-methylamino-L-alanine and amyotrophic lateral sclerosis.Toxins · 2010Review
- The accuracy of discharge diagnosis coding for Amyotrophic Lateral Sclerosis in a large teaching hospital.European journal of epidemiology · 2009Article
- The Rotterdam Study: 2010 objectives and design update.European journal of epidemiology · 2009Article
- Biomedical ontologies in action: role in knowledge management, data integration and decision support.Yearbook of medical informatics · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Amyotrophic lateral sclerosis (ALS) is a rare and devastating neurological disorder of the adult age with a prognosis of about 2-3 years from the onset of the disease. No clear cause has been identified but it seems to be a multifactorial disease with genetic and environmental components involved. Increments of mortality rates were observed since 1980 both in Italy and in many other countries. The objective of the present study is to describe the distribution of ALS mortality in Italy in the period 1980-2001 detecting single municipalities or clusters with high mortality levels for motor neuron disease (MND). ALS represents the main part (85%) of the MND group which is globally identified by the IX ICD (International Classification of Diseases and Causes of Death) 335.2 code. Death numbers and standardized mortality ratios (SMR) for MND were calculated for all Italian municipalities through the ENEA mortality database system (data source: National Institute of Statistics-ISTAT), using national mortality rates as reference. Subsequently, in order to detect municipal clusters, spatial analysis was performed. Out of the 8,099 Italian municipalities, 132 where characterized by SMR values higher than expected. Moreover 16 clusters with significant high relative risk values (RR) were identified, 12 out of them including only a single municipality. Only 22 of the municipalities with high SMR were included in the clusters. In conclusion, the two different epidemiological methodologies demonstrated to be widely complementary in detecting the geographical distribution of the disease in terms of risk for populations. A first selection of the priority areas where analytical studies should be carried on, in order to identify risk factors associated to ALS, is tentatively suggested.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.