ArticleJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry2007
Effect of vanadate on gene expression of the insulin signaling pathway in skeletal muscle of streptozotocin-induced diabetic rats.
Article in Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 27 citations in OpenAlex.
- Insulin Receptor Substrates Regulation and Clinical Responses Following Vanadium-Enriched Yeast Supplementation in Obese Type 2 Diabetic Patients: a Randomized, Double-Blind, Placebo-Controlled Clinical Trial.Biological trace element research · 2023Trial
- Comparison of the Effects of Sodium Orthovanadate and Sodium Metavanadate on the Growth and Survival of DU-145 Prostate Cancer Cells.Biological trace element research · 2026Article
- The Influence of Organic Vanadium Complexes on an Antioxidant Profile in Adipose Tissue in Wistar Rats.Materials (Basel, Switzerland) · 2022Article
- A Dioxidovanadium ComplexEvidence-based complementary and alternative medicine : eCAM · 2022Article
- Anticancer effect of sodium metavanadate on murine breast cancer both in vitro and in vivo.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2021Article
- Vanadium in Biosphere and Its Role in Biological Processes.Biological trace element research · 2018Review
- Vanadyl sulfate treatment stimulates proliferation and regeneration of beta cells in pancreatic islets.Journal of diabetes research · 2014Article
- Vanadyl acetylacetonate upregulates PPARγ and adiponectin expression in differentiated rat adipocytes.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2013Article
- Transcriptomic analysis of insulin-sensitive tissues from anti-diabetic drug treated ZDF rats, a T2DM animal model.PloS one · 2013Article
- Effect of V(IV)O(dipic-Cl)(H2O)2 on Lipid Metabolism Disorders in the Liver of STZ-Induced Diabetic Rats.Journal of diabetes research · 2013Article
- Anti-diabetic effects of a series of vanadium dipicolinate complexes in rats with streptozotocin-induced diabetes.Coordination chemistry reviews · 2011Article
- Gene expression module-based chemical function similarity search.Nucleic acids research · 2008Article
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3 authors at 1 institution in 1 country.
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Abstract
An insulin signaling pathway microarray was used to evaluate the gene expression profiling of the insulin signaling pathway in the skeletal muscle of streptozotocin-induced diabetic, NaVO(3)-treated diabetic and insulin-treated diabetic rats for the investigation of the effect of vanadium and insulin on the insulin signaling pathway. Of 96 genes surveyed, transcriptional patterns of 19 genes (20%) showed alterations in diabetic rats compared with controls. Although most of these changed gene expressions were improved after treatment with NaVO(3) (14, 74%) and insulin (16, 84%), NaVO(3) and insulin treatment resulted in the alteration of 20 and 12 additional gene transcripts compared no treatment. We found that both NaVO(3) and insulin treatment achieved a desirable glucose level and most of the alterative gene transcripts in diabetic rats were normalized with NaVO(3) and insulin treatment. Comparison of the gene expression profiling indicates that there is a significant difference between the NaVO(3)-treated group and the insulin-treated group. The present study demonstrated for the first time that several candidate genes of the insulin signaling pathway are involved in the effect of vanadium treatment on hyperglycemia. This study opens the way for more focused investigations that may identify the genes responsible for diabetes and vanadium treatment in the global insulin signaling pathway.
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