ArticlePediatric nephrology (Berlin, Germany)2007
Low birth weight, but not postnatal weight gain, aggravates the course of nephrotic syndrome.
Article in Pediatric nephrology (Berlin, Germany), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 31 citations in OpenAlex.
- Prediction Models and Risk Factors for Steroid Resistance in Children with Nephrotic Syndrome: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2026Review
- Effect of laparoscopic sleeve gastrectomy on heart remodeling and right ventricular function.Caspian journal of internal medicine · 2026Article
- Relationship betweenCaspian journal of internal medicine · 2023Article
- Premature birth carries a higher risk of nephrotic syndrome: a cohort study.Scientific reports · 2021Article
- Association of low birth weight and prematurity with clinical outcomes of childhood nephrotic syndrome: a prospective cohort study.Pediatric nephrology (Berlin, Germany) · 2019Article
- Low birth weight is a conditioning factor for podocyte alteration and steroid dependance in children with nephrotic syndrome.Journal of nephrology · 2018Article
- Developmental origins of chronic renal disease: an integrative hypothesis.International journal of nephrology · 2013Review
- Fetal programming of renal function.Pediatric nephrology (Berlin, Germany) · 2012Review
- Adverse consequences of accelerated neonatal growth: cardiovascular and renal issues.Pediatric nephrology (Berlin, Germany) · 2011Review
- Serum creatinine levels are significantly influenced by renal size in the normal pediatric population.Clinical journal of the American Society of Nephrology : CJASN · 2011Article
- The implications of fetal programming of glomerular number and renal function.Journal of molecular medicine (Berlin, Germany) · 2009Article
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Authors and funding
8 authors at 2 institutions in 1 country.
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Abstract
Clinical and animal studies have shown a higher risk of an aggravated course of renal disease in childhood after birth for babies small for gestational age (SGA). In addition relative "supernutrition" and fast weight gain in early infancy seem to support the development of later disease. In a retrospective analysis of 62 cases of idiopathic nephrotic syndrome treated between 1994 and 2004 at a university centre for paediatric nephrology, we related the course of disease to birth weight and to the weight gain in the first 2 years of life. Six children were born SGA (birth weight <-1.5 standard deviation score), and 56 were born as appropriate for gestational age (AGA). In all SGA children renal biopsy was performed, while only 55% of the AGA children underwent renal biopsy (P = 0.07), showing no difference in renal histology. In the SGA group, four of six patients developed steroid resistance (vs 12/56 AGA, P < 0.05). Of the SGA children, 83% needed antihypertensive treatment in the course of the disease compared to 39% of the AGA children (P = 0.07). The extent of weight gain between birth and 24 months of age did not influence the course of disease. In conclusion, we were able to find evidence for an aggravated course of idiopathic nephrotic syndrome in former SGA children. Independently of birth weight, weight gain in the first 2 years of life did not influence the course of disease.
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