Evidence map›Paper›PMID 17874137›Full record

Trial reportPediatric nephrology (Berlin, Germany)2007

NGAL is an early predictive biomarker of contrast-induced nephropathy in children.

Russel Hirsch, Catherine Dent, Holly Pfriem, Janene Allen, Robert H Beekman, Qing Ma, Sudha Dastrala, Michael Bennett, Mark Mitsnefes, Prasad Devarajan

Abstract readClinical Trial
PubMed Publisher
In one paragraph

Trial report in Pediatric nephrology (Berlin, Germany), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 167 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
167citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

167 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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  14. Urinary biomarkers and renal recovery in critically ill patients with renal support.Clinical journal of the American Society of Nephrology : CJASN · 2011
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107 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Russel HirschDivision of Cardiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Catherine Dent
Holly Pfriem
Janene Allen
Robert H Beekman
Qing Ma
Sudha Dastrala
Michael Bennett
Mark Mitsnefes
Prasad Devarajan

Funding

STRUCTURAL AND FUNCTIONAL DEVELOPMENT OF THE KIDNEYP50DK052612 · NIDDK · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI GOMEZ, ROBERTO ARIEL · 1997 to 2006
$6.8M
ANKYRIN: CRUCIAL LINKER IN RENAL CELL APOPTOTIC CASCADESR01DK053289 · NIDDK · MONTEFIORE MEDICAL CENTER (BRONX, NY) · PI DEVARAJAN, PRASAD · 2000 to 2003
$674k
NGAL: A novel early biomarker of acute renal injuryR21DK070163 · NIDDK · CHILDREN'S HOSPITAL MED CTR (CINCINNATI) · PI DEVARAJAN, PRASAD · 2004 to 2005
$410k
NIDDK NIH HHS P50-DK52612NIDDK NIH HHS R01-DK53289NIDDK NIH HHS R21-DK070163
6 · The paper itself

Abstract

We hypothesized that neutrophil gelatinase-associated lipocalin (NGAL) is an early predictive biomarker of contrast-induced nephropathy (CIN). We prospectively enrolled 91 children (age 0-18 years) with congenital heart disease undergoing elective cardiac catheterization and angiography with contrast administration (CC; Ioversol). Serial urine and plasma samples were analyzed in a double-blind fashion by NGAL enzyme-linked immunosorbent assay (ELISA). CIN, defined as a 50% increase in serum creatinine from baseline, was found in 11 subjects (12%), but detection using increase in serum creatinine was only possible 6-24 h after CC. In contrast, significant elevation of NGAL concentrations in urine (135 +/- 32 vs. 11.6 +/- 2 ng/ml without CIN, p < 0.001) and plasma (151 +/- 34 vs. 36 +/- 4 without CIN, p < 0.001) were noted within 2 h after CC in those subjects. Using a cutoff value of 100 ng/ml, sensitivity, specificity, and area under the receiver-operating characteristic (ROC) curve for prediction of CIN were excellent for the 2-h urine NGAL (73%, 100%, and 0.92, respectively) and 2-h plasma NGAL (73%, 100%, and 0.91, respectively). By multivariate analysis, the 2-h NGAL concentrations in the urine (R (2) = 0.52, p < 0.0001) and plasma (R (2) = 0.72, p < 0.0001) were found to be powerful independent predictors of CIN. Patient demographics and contrast volume were not predictive of CIN.

Indexed as

Acute-Phase ProteinsAngiographyBiomarkersCardiac CatheterizationChildContrast MediaCreatinineDouble-Blind MethodEnzyme-Linked Immunosorbent AssayFemaleHeart Defects, CongenitalHumansKidney DiseasesLipocalin-2LipocalinsMaleAcute-Phase ProteinsBiomarkersContrast MediaCreatinineioversolLCN2 protein, humanLipocalin-2LipocalinsProto-Oncogene ProteinsTriiodobenzoic Acids

Identifiers

PMID17874137

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.