ReviewImmunogenetics2007
Genetics-squared: combining host and pathogen genetics in the analysis of innate immunity and bacterial virulence.
Review in Immunogenetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Using host and bacterial genetic approaches to define virulence strategies and protective immunity duringmSphere · 2025Review
- Murine Models of Salmonella Infection.Current protocols · 2023Article
- Article
- Article
- mSphere of Influence: Combining Host and Pathogen Genetics To Disrupt Chronic Infections.mSphere · 2020Article
- Listeriolysin O: A phagosome-specific cytolysin revisited.Cellular microbiology · 2019Review
- Molecular phenotyping of infection-associated small non-coding RNAs.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
- Streptococcus pyogenes biofilm growth in vitro and in vivo and its role in colonization, virulence, and genetic exchange.The Journal of infectious diseases · 2014Article
- Systems mapping of HIV-1 infection.BMC genetics · 2012Article
- The Legionella IcmSW complex directly interacts with DotL to mediate translocation of adaptor-dependent substrates.PLoS pathogens · 2012Article
- Interaction of Salmonella typhimurium with dendritic cells derived from pluripotent embryonic stem cells.PloS one · 2012Article
- How to become a top model: impact of animal experimentation on human Salmonella disease research.Infection and immunity · 2011Review
- Article
- Dissecting the genetic architecture of host-pathogen specificity.PLoS pathogens · 2010Article
- Host-detrimental role of Esx-1-mediated inflammasome activation in mycobacterial infection.PLoS pathogens · 2010Article
- A pathogenesis assay using Saccharomyces cerevisiae and Caenorhabditis elegans reveals novel roles for yeast AP-1, Yap1, and host dual oxidase BLI-3 in fungal pathogenesis.Eukaryotic cell · 2009Article
- Patterns of pathogenesis: discrimination of pathogenic and nonpathogenic microbes by the innate immune system.Cell host & microbe · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The interaction of bacterial pathogens with their hosts' innate immune systems can be extremely complex and is often difficult to disentangle experimentally. Using mouse models of bacterial infections, several laboratories have successfully applied genetic approaches to identify novel host genes required for innate immune defense. In addition, a variety of creative bacterial genetic schemes have been developed to identify key bacterial genes involved in triggering or evading host immunity. In cases where both the host and pathogen are amenable to genetic manipulation, a combination of host and pathogen genetic approaches can be used. Focusing on bacterial infections of mice, this review summarizes the benefits and limitations of applying genetic analysis to the study of host-pathogen interactions. In particular, we consider how prokaryotic and eukaryotic genetic strategies can be combined, or "squared," to yield new insights in host-pathogen biology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.