ArticleEuropean journal of clinical pharmacology2007
Evaluation of patients' experiences with antidepressants reported by means of a medicine reporting system.
Article in European journal of clinical pharmacology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Estimating Adverse Events Associated With Herbal Medicines Using Pharmacovigilance Databases: Systematic Review and Meta-Analysis.JMIR public health and surveillance · 2024Pooled it
- Efficacy of Horticultural Therapy on Positive, Negative, and Affective Symptoms in Individuals with Schizophrenia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Healthcare (Basel, Switzerland) · 2024Review
- Effects of Visual Art Therapy on Positive Symptoms, Negative Symptoms, and Emotions in Individuals with Schizophrenia: A Systematic Review and Meta-Analysis.Healthcare (Basel, Switzerland) · 2024Review
- Identifying Unmet Needs in Major Depressive Disorder Using a Computer-Assisted Alternative to Conventional Thematic Analysis: Qualitative Interview Study With Psychiatrists.JMIR formative research · 2024Article
- Art Therapy: A Complementary Treatment for Mental Disorders.Frontiers in psychology · 2021Review
- Serotonin and Antidepressant SSRIs Inhibit Rat Neuroendocrine Dopamine Neurons: Parallel Actions in the Lactotrophic Axis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Patient Participation and the Use of Ehealth Tools for Pharmacoviligance.Frontiers in pharmacology · 2016Review
- Pharmacovigilance from social media: mining adverse drug reaction mentions using sequence labeling with word embedding cluster features.Journal of the American Medical Informatics Association : JAMIA · 2015Article
- Consumer Narratives in ADR Reporting: An Important Aspect of Public Health? Experiences from Reports to a Swedish Consumer Organization.Frontiers in public health · 2015Article
- Profile of vortioxetine in the treatment of major depressive disorder: an overview of the primary and secondary literature.Therapeutics and clinical risk management · 2015Review
- Implementing guidelines for depression on antidepressant prescribing in general practice: a quasi-experimental evaluation.BMC family practice · 2014Article
- Antidepressants in primary care: patients' experiences, perceptions, self-efficacy beliefs, and nonadherence.Patient preference and adherence · 2014Article
- A Pill for the Ill? Patients' Reports of Their Experience of the Medical Encounter in the Treatment of Depression.PloS one · 2013Article
- Experiences from consumer reports on psychiatric adverse drug reactions with antidepressant medication: a qualitative study of reports to a consumer association.BMC pharmacology & toxicology · 2012Article
- Reasons for and time to discontinuation of rimonabant therapy: a modified prescription-event monitoring study.Drug safety · 2012Article
- Economic factors in of patients' nonadherence to antidepressant treatment.Social psychiatry and psychiatric epidemiology · 2012Article
- What can we learn from consumer reports on psychiatric adverse drug reactions with antidepressant medication? Experiences from reports to a consumer association.BMC clinical pharmacology · 2011Article
- Current awareness: pharmacoepidemiology and drug safety.Pharmacoepidemiology and drug safety · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess experiences related to antidepressant use reported to an internet-based medicine reporting system and to compare the nature of the side effects reported by patients with those reported by health care professionals (HCPs).
methodsAll reports submitted from May 2004 to May 2005 to an internet-based medicine reporting system in The Netherlands related to the use of antidepressants were analysed. Spontaneous reports of adverse drug reactions on antidepressants from HCPs received by The Netherlands Pharmacovigilance Centre Lareb from May 2004 to May 2005 were included for comparison.
resultsOf the 2232 individuals who submitted a report to the internet-based medicine reporting system, 258 submitted a report on antidepressants. Of these, 92 individuals (36%) reported on effectiveness, 40 (16%) of whom reported on ineffectiveness, and 217 (84%) submitted a report on side effects, with 202 (78%) reporting a total of 630 side effects that were experienced as negative. Fourteen individuals (5%) reported a practical issue and four (2%) reported a reimbursement issue. Of all 630 side effects reported, 48% resulted in the patient discontinuing the antidepressant therapy; of these 29% did not inform their HCP. Of all the side effects reported, 52% were perceived as "very negative". In comparison to the side effects reported by HCPs, patients more often reported apathy, excessive sweating, ineffectiveness, somnolence, insomnia, sexual problems and weight increase.
conclusionPatients report the ineffectiveness and side effects of antidepressant therapy as negative and leading to discontinuation of the therapy. Patients and HCPs differ in the nature of the reported side effects. Patient experiences should be included in the evaluation of antidepressant treatment in clinical practice.
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Registered trials
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