ArticlePsychopharmacology2007
A PET study on regional coexpression of 5-HT1A receptors and 5-HTT in the human brain.
Article in Psychopharmacology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 39 citations in OpenAlex.
- More and Less Fear in Serotonin Transporter Knockout Mice.Genes, brain, and behavior · 2025Article
- A positron emission tomography study of the serotonergic system in relation to anxiety in depression.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2017Article
- Lack of association between the serotonin transporter and serotonin 1A receptor: an in vivo PET imaging study in healthy adults.Psychiatry research. Neuroimaging · 2016Article
- Increased Serotonin Transporter Expression Reduces Fear and Recruitment of Parvalbumin Interneurons of the Amygdala.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- SERT and uncertainty: serotonin transporter expression influences information processing biases for ambiguous aversive cues in mice.Genes, brain, and behavior · 2015Article
- Variation in serotonin transporter expression modulates fear-evoked hemodynamic responses and theta-frequency neuronal oscillations in the amygdala.Biological psychiatry · 2014Article
- Mapping neurotransmitter networks with PET: an example on serotonin and opioid systems.Human brain mapping · 2014Article
- Article
- 5-HT radioligands for human brain imaging with PET and SPECT.Medicinal research reviews · 2013Review
- Endophenotypes as a measure of suicidality.Journal of applied genetics · 2012Review
- Transcriptional regulation of the 5-HT1A receptor: implications for mental illness.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2012Review
- Serotonin transporter occupancy with TCAs and SSRIs: a PET study in patients with major depressive disorder.The international journal of neuropsychopharmacology · 2012Article
- Presynaptic 5-HT1A is related to 5-HTT receptor density in the human brain.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2011Article
- Localization of 5-HT1A and 5-HT2A positive cells in the brainstems of control age-matched and Alzheimer individuals.Age (Dordrecht, Netherlands) · 2010Article
- A nonlinear relationship between cerebral serotonin transporter and 5-HT(2A) receptor binding: an in vivo molecular imaging study in humans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- The molecular background of sex difference in depressive disorders: still an enigma.European journal of nuclear medicine and molecular imaging · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleSeveral lines of evidence suggest inter-dependency between the serotonin transporter (5-HTT) and the 5HT1A receptor, two recognised targets for the treatment of anxiety and depression.
objectivesto examine the correlation of regional expression levels for these two serotonergic markers in the human brain in vivo.
methodsTwelve male control subjects were examined with PET twice on the same day, using the radioligands [11C]WAY 100635 and [11C]MADAM for quantification of the 5-HT1A receptor and the 5-HTT, respectively. The binding potential (BP) was calculated for raphe nuclei, hippocampus and frontal cortex.
resultsIn all regions, the BP for both [11C]WAY 100635 (raphe nuclei 1.85-4.71, hippocampus 2.52-6.17, frontal cortex 2.03-3.79) and [11C]MADAM (2.70-7.65, 0.47-1.76, 0.18-0.51) varied several fold between subjects. In the raphe nuclei, where the two markers are situated on the same neurons, the ratio of [11C]WAY 100635 binding to [11C]MADAM BP binding varied considerably (0.43-1.05). There was a positive correlation between the two markers in the raphe nuclei (rxy=0.68, p<0.05) and in the hippocampus (rxy=0.97, p<0.001) but not in the frontal cortex (rxy=-0.25, p=0.44).
conclusionsThe results support a correlation between density levels of the 5-HT1A-receptor and the 5-HTT in the raphe nuclei and hippocampus but not in the frontal cortex. A suggested clinical implication is that the inter-individual variability in 5-HT1A-receptor and 5-HTT densities, as well as the ratio of these, is of particular interest in relation to individual responses to selective serotonin reuptake inhibitor treatment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.