ReviewMedical molecular morphology2007
In situ production of sex steroids in human breast carcinoma.
Review in Medical molecular morphology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 42 citations in OpenAlex.
- Breast Cancer: Targeting of Steroid Hormones in Cancerogenesis and Diagnostics.International journal of molecular sciences · 2021Review
- AKR1C3 (type 5 17β-hydroxysteroid dehydrogenase/prostaglandin F synthase): Roles in malignancy and endocrine disorders.Molecular and cellular endocrinology · 2019Review
- Structural and Functional Biology of Aldo-Keto Reductase Steroid-Transforming Enzymes.Endocrine reviews · 2019Review
- Current knowledge of the multifunctional 17β-hydroxysteroid dehydrogenase type 1 (HSD17B1).Gene · 2016Review
- Steroid Tumor Environment in Male and Female Mice Model of Canine and Human Inflammatory Breast Cancer.BioMed research international · 2016Article
- Intratumoral estrogen sulfotransferase induction contributes to the anti-breast cancer effects of the dithiocarbamate derivative TM208.Acta pharmacologica Sinica · 2015Article
- Promiscuity and diversity in 3-ketosteroid reductases.The Journal of steroid biochemistry and molecular biology · 2015Review
- Endometriosis still a challenge.Journal of medicine and life · 2014Review
- Androgen resistance in female mice increases susceptibility to DMBA-induced mammary tumors.Hormones & cancer · 2012Article
- Molecular therapy of breast cancer: progress and future directions.Nature reviews. Endocrinology · 2010Review
- Androgens in human breast carcinoma.Medical molecular morphology · 2010Review
- Testosterone membrane-initiated action in breast cancer cells: Interaction with the androgen signaling pathway and EPOR.Molecular oncology · 2010Article
- Aldo-keto reductase 1C3 expression in MCF-7 cells reveals roles in steroid hormone and prostaglandin metabolism that may explain its over-expression in breast cancer.The Journal of steroid biochemistry and molecular biology · 2010Article
- Expression of estrogenicity genes in a lineage cell culture model of human breast cancer progression.Breast cancer research and treatment · 2010Article
- The Role of Androgens in Normal and Malignant Breast Tissue.Breast care (Basel, Switzerland)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is well known that sex steroids are closely involved in the growth of human breast carcinomas, and the great majority of breast carcinomas express sex steroid receptors. In particular, recent studies have demonstrated that estrogens and androgens are locally produced and act in breast carcinoma tissues without release into plasma. Blockade of intratumoral estrogen production potentially leads to an improvement in the prognosis of invasive breast carcinoma patients, and, therefore, it is important to obtain a better understanding of sex steroid-producing enzymes in breast carcinoma. In this review, we summarize recent studies on tissue concentration of sex steroids and expression of enzymes related to intratumoral production of estrogens [aromatase, steroid sulfatase (STS), and 17beta-hydroxysteroid dehydrogenase type 1 (17betaHSD1)], and androgens (17betaHSD5 and 5alpha-reductase) in invasive and in situ (noninvasive) breast carcinomas, and discuss the significance of intratumoral production of sex steroids in breast carcinoma.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.