ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2008
Correlates of bone mineral density in men of African ancestry: the Tobago bone health study.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 4 of them syntheses that pooled it.
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Who cites it
40 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Pooled it
- A Meta-Analysis of the Transferability of Bone Mineral Density Genetic Loci Associations From European to African Ancestry Populations.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2021Pooled it
- Aspirin and fracture risk: a systematic review and exploratory meta-analysis of observational studies.BMJ open · 2020Pooled it
- Genome-wide association and follow-up replication studies identified ADAMTS18 and TGFBR3 as bone mass candidate genes in different ethnic groups.American journal of human genetics · 2009Pooled it
- Thigh and Calf Myosteatosis are Strongly Associated with Muscle and Physical Function in African Caribbean Men.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Replacing sedentary time with light activity was associated with less adiposity across several depots in African ancestry men.Obesity (Silver Spring, Md.) · 2022Article
- Protective Effects of Higher Exposure to Aspirin and/or Clopidogrel on the Occurrence of Hip Fracture among Diabetic Patients: A Retrospective Cohort Study.Biomedicines · 2022Article
- Hepatic and Skeletal Muscle Adiposity Are Associated with Diabetes Independent of Visceral Adiposity in Nonobese African-Caribbean Men.Metabolic syndrome and related disorders · 2020Article
- Wnt Pathway Gene Expression Is Associated With Arterial Stiffness.Journal of the American Heart Association · 2020Article
- Arterial stiffness and hypertension status in Afro-Caribbean men.Journal of hypertension · 2019Article
- Wnt Pathway Inhibitor DKK1: A Potential Novel Biomarker for Adiposity.Journal of the Endocrine Society · 2019Article
- Association of ectopic fat with abdominal aorto-illiac and coronary artery calcification in african ancestry men.Atherosclerosis · 2017Article
- Gastroesophageal reflux disease with proton pump inhibitor use is associated with an increased risk of osteoporosis: a nationwide population-based analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016Article
- Association of Circulating Renin and Aldosterone With Osteocalcin and Bone Mineral Density in African Ancestry Families.Hypertension (Dallas, Tex. : 1979) · 2016Article
- Optimal serum cholesterol concentrations are associated with accelerated bone loss in African ancestry men.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016Article
- Renal Function and Bone Loss in a Cohort of Afro-Caribbean Men.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2015Article
- Association of circulating sclerostin with vascular calcification in Afro-Caribbean men.Atherosclerosis · 2015Article
- Heritability and genetics of serum dickkopf 1 levels in African ancestry families.Calcified tissue international · 2015Article
- Race/ethnic differences in associations between bone mineral density and fracture history in older men.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014Article
- Association of volumetric bone mineral density with abdominal aortic calcification in African ancestry men.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
unlabelledCorrelates of BMD were examined in a cross-sectional analysis of men of West African ancestry. BMD, measured at the total hip and the femoral neck subregion, was associated with age, anthropometric, lifestyle, and medical factors in multiple linear regression models. These models explained 25-27% of the variability in total hip and femoral neck BMD, respectively, and 13% of the variability in estimated volumetric BMD.
objectiveTo examine the correlates of bone mineral density (BMD) in men of West African ancestry.
methodsTwo thousand five hundred and one men aged 40 to 93 years were recruited from the Caribbean Island of Tobago. Participants completed a questionnaire and physical examination. We measured hip BMD and body composition, using DXA. Volumetric BMD was estimated as bone mineral apparent density (BMAD).
resultsBMD was 10% and 20% higher in African Caribbean males compared to U.S. non-Hispanic black and white males, respectively. In multiple linear regression models, greater lean mass, history of working on a fishing boat or on a farm, frequent walking, and self-reported diabetes were significantly associated with higher BMD. Fat mass, history of farming, and self-reported hypertension were also associated with higher BMAD. Older age, mixed African ancestry, and history of a fracture were associated with lower BMD and BMAD. Lean body mass explained 20%, 18% and 6% of the variance in BMD at the total hip, femoral neck and BMAD, respectively.
conclusionsAfrican Caribbean males have the highest BMD on a population level ever reported. Lean mass was the single most important correlate. Variability in BMD/BMAD was also explained by age, mixed African ancestry, anthropometric, lifestyle, and medical factors.
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