ArticleNature genetics2007
A genome-wide association study of global gene expression.
Article in Nature genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 581 papers, 20 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
581 citing papers in PubMed, 20 syntheses or guidelines pooled it, 962 citations in OpenAlex.
- Replication and meta-analyses nominate numerous eosinophilic esophagitis risk genes.The Journal of allergy and clinical immunology · 2021Pooled it
- Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.Nature communications · 2017Pooled it
- A meta-analysis of genome-wide association studies of asthma in Puerto Ricans.The European respiratory journal · 2017Pooled it
- Finding lost genes in GWAS via integrative-omics analysis reveals novel sub-networks associated with preterm birth.Human molecular genetics · 2016Pooled it
- Common variants at PVT1, ATG13-AMBRA1, AHI1 and CLEC16A are associated with selective IgA deficiency.Nature genetics · 2016Pooled it
- Pooled it
- Association, characterisation and meta-analysis of SNPs linked to general reading ability in a German dyslexia case-control cohort.Scientific reports · 2016Pooled it
- Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia.Nature communications · 2016Pooled it
- Genetic studies of body mass index yield new insights for obesity biology.Nature · 2015 · on this mapPooled it
- Trans-ethnic meta-analysis of white blood cell phenotypes.Human molecular genetics · 2014Pooled it
- Ankylosing spondylitis is associated with the anthrax toxin receptor 2 gene (ANTXR2).Annals of the rheumatic diseases · 2014Pooled it
- Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens.Nature genetics · 2014Pooled it
- Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma.Nature genetics · 2014Pooled it
- Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins.Nature communications · 2014Pooled it
- A meta-analysis of gene expression quantitative trait loci in brain.Translational psychiatry · 2014Pooled it
- Genome-wide interaction studies reveal sex-specific asthma risk alleles.Human molecular genetics · 2014Pooled it
- Integrative genomics reveals novel molecular pathways and gene networks for coronary artery disease.PLoS genetics · 2014Pooled it
- Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci.American journal of human genetics · 2014Pooled it
- Common mechanisms underlying refractive error identified in functional analysis of gene lists from genome-wide association study results in 2 European British cohorts.JAMA ophthalmology · 2014Pooled it
- Large-scale genome-wide association studies and meta-analyses of longitudinal change in adult lung function.PloS one · 2014Pooled it
521 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
Abstract
We have created a global map of the effects of polymorphism on gene expression in 400 children from families recruited through a proband with asthma. We genotyped 408,273 SNPs and identified expression quantitative trait loci from measurements of 54,675 transcripts representing 20,599 genes in Epstein-Barr virus-transformed lymphoblastoid cell lines. We found that 15,084 transcripts (28%) representing 6,660 genes had narrow-sense heritabilities (H2) > 0.3. We executed genome-wide association scans for these traits and found peak lod scores between 3.68 and 59.1. The most highly heritable traits were markedly enriched in Gene Ontology descriptors for response to unfolded protein (chaperonins and heat shock proteins), regulation of progression through the cell cycle, RNA processing, DNA repair, immune responses and apoptosis. SNPs that regulate expression of these genes are candidates in the study of degenerative diseases, malignancy, infection and inflammation. We have created a downloadable database to facilitate use of our findings in the mapping of complex disease loci.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.