ArticleNature genetics2007
Discovery of expression QTLs using large-scale transcriptional profiling in human lymphocytes.
Article in Nature genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 316 papers, 15 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
316 citing papers in PubMed, 15 syntheses or guidelines pooled it, 535 citations in OpenAlex.
- Trans-ethnic meta-analysis of white blood cell phenotypes.Human molecular genetics · 2014Pooled it
- Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins.Nature communications · 2014Pooled it
- Meta-analysis on blood transcriptomic studies identifies consistently coexpressed protein-protein interaction modules as robust markers of human aging.Aging cell · 2014Pooled it
- Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci.American journal of human genetics · 2014Pooled it
- Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease.The American journal of clinical nutrition · 2013Pooled it
- Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake.The American journal of clinical nutrition · 2013Pooled it
- Loci influencing blood pressure identified using a cardiovascular gene-centric array.Human molecular genetics · 2013Pooled it
- Clinical and genetic correlates of growth differentiation factor 15 in the community.Clinical chemistry · 2012Pooled it
- Novel late-onset Alzheimer disease loci variants associate with brain gene expression.Neurology · 2012Pooled it
- Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways.Nature genetics · 2012Pooled it
- Genome-wide association and functional follow-up reveals new loci for kidney function.PLoS genetics · 2012Pooled it
- Genome-wide association of pericardial fat identifies a unique locus for ectopic fat.PLoS genetics · 2012Pooled it
- Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.PLoS genetics · 2012Pooled it
- Brain expression genome-wide association study (eGWAS) identifies human disease-associated variants.PLoS genetics · 2012Pooled it
- CUBN is a gene locus for albuminuria.Journal of the American Society of Nephrology : JASN · 2011Pooled it
- Dissecting the genetics of the human transcriptome identifies novel trait-related trans-eQTLs and corroborates the regulatory relevance of non-protein coding loci†.Human molecular genetics · 2015Trial
- Trial
- Identification of genetic variants influencing the human plasma proteome.Proceedings of the National Academy of Sciences of the United States of America · 2013Trial
- Advancing age is associated with gene expression changes resembling mTOR inhibition: evidence from two human populations.Mechanisms of ageing and development · 2012Trial
- Machine learning and statistical methods for molecular quantitative trait loci.Nature reviews. Genetics · 2026Review
256 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
17 authors at 5 institutions in 2 countries.
Funding
Abstract
Quantitative differences in gene expression are thought to contribute to phenotypic differences between individuals. We generated genome-wide transcriptional profiles of lymphocyte samples from 1,240 participants in the San Antonio Family Heart Study. The expression levels of 85% of the 19,648 detected autosomal transcripts were significantly heritable. Linkage analysis uncovered >1,000 cis-regulated transcripts at a false discovery rate of 5% and showed that the expression quantitative trait loci with the most significant linkage evidence are often located at the structural locus of a given transcript. To highlight the usefulness of this much-enlarged map of cis-regulated transcripts for the discovery of genes that influence complex traits in humans, as an example we selected high-density lipoprotein cholesterol concentration as a phenotype of clinical importance, and identified the cis-regulated vanin 1 (VNN1) gene as harboring sequence variants that influence high-density lipoprotein cholesterol concentrations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.