ReviewGenetics in medicine : official journal of the American College of Medical Genetics2007
Ethical implications of array comparative genomic hybridization in complex phenotypes: points to consider in research.
Review in Genetics in medicine : official journal of the American College of Medical Genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- To tell or not to tell? A systematic review of ethical reflections on incidental findings arising in genetics contexts.European journal of human genetics : EJHG · 2013Pooled it
- Practical guidelines addressing ethical issues pertaining to the curation of human locus-specific variation databases (LSDBs).Human mutation · 2010Guideline
- Ethical issues in genomics research on neurodevelopmental disorders: a critical interpretive review.Human genomics · 2021Review
- Article
- Parents' perceptions of the usefulness of chromosomal microarray analysis for children with autism spectrum disorders.Journal of autism and developmental disorders · 2015Article
- Incidental findings from clinical genome-wide sequencing: a review.Journal of genetic counseling · 2014Review
- Priorities for autism spectrum disorder risk communication and ethics.Autism : the international journal of research and practice · 2013Article
- Parents' perspectives on participating in genetic research in autism.Journal of autism and developmental disorders · 2013Article
- Ethical issues in neonatal and pediatric clinical trials.Pediatric clinics of North America · 2012Review
- "What does it mean?": uncertainties in understanding results of chromosomal microarray testing.Genetics in medicine : official journal of the American College of Medical Genetics · 2012Article
- Clinical impact of copy number variation analysis using high-resolution microarray technologies: advantages, limitations and concerns.Genome medicine · 2012Review
- Social Responsiveness Scale-aided analysis of the clinical impact of copy number variations in autism.Neurogenetics · 2011Article
- Risk factors for autism: translating genomic discoveries into diagnostics.Human genetics · 2011Review
- What is a meaningful result? Disclosing the results of genomic research in autism to research participants.European journal of human genetics : EJHG · 2010Article
- Translating genomics into the clinic: moving to the post-Mendelian world.Genome medicine · 2009Article
- Understanding incidental findings in the context of genetics and genomics.The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics · 2008Article
- Ethical and social implications of genetic testing for communication disorders.Journal of communication disordersReview
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
As with many new diagnostic technologies, the recent rapid emergence of array comparative genome hybridization in clinical genetics provides the power to observe new biological phenomena before their clinical significance is well understood. This raises ethical issues for clinicians when applying the technologies. However, at this early stage of research and development on array comparative genome hybridization, the ethical implications of the conduct of research, as well as how research findings are presented and interpreted, should also be considered by the research, clinical, and ethics communities. These considerations are especially important in the use of array comparative genome hybridization to study complex and common traits. We examined recent publications on autism as an example of the application of array comparative genome hybridization to a complex phenotype. Our goal was to identify points to consider for researchers, clinicians, and patients/families to ensure responsible and ethical design, presentation, and interpretation of these kinds of studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.