ArticleCell cycle (Georgetown, Tex.)2007
Neural potential of a stem cell population in the hair follicle.
Article in Cell cycle (Georgetown, Tex.), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
37 citing papers in PubMed.
- Bulge-Derived Epithelial Cells Isolated from Human Hair Follicles Using Enzymatic Digestion or Explants Result in Comparable Tissue-Engineered Skin.International journal of molecular sciences · 2025Article
- The beneficial effects of chick embryo extract preconditioning on hair follicle stem cells: A promising strategy to generate Schwann cells.Cell proliferation · 2023Article
- Detection of De Novo Dividing Stem Cells In Situ through Double Nucleotide Analogue Labeling.Cells · 2022Article
- S100A6 as a Constituent and Potential Marker of Adult and Cancer Stem Cells.Stem cell reviews and reports · 2022Review
- Hair Follicle Stem Cells for Tissue Regeneration.Tissue engineering. Part B, Reviews · 2022Review
- The Rho guanosine nucleotide exchange factors Vav2 and Vav3 modulate epidermal stem cell function.Oncogene · 2022Article
- Mechanotransductive Differentiation of Hair Follicle Stem Cells Derived from Aged Eyelid Skin into Corneal Endothelial-Like Cells.Stem cell reviews and reports · 2022Article
- Hair Follicle Grafting Therapy Promotes Re-Emergence of Critical Skin Components in Chronic Nonhealing Wounds.JID innovations : skin science from molecules to population health · 2021Article
- Article
- Mouse Models for Studying Hippocampal Adult Neural Stem Cell Biology.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Transgenic models for investigating the nervous system: Currently available neurofluorescent reporters and potential neuronal markers.Biochimica et biophysica acta. General subjects · 2020Review
- Adult enteric nervous system in health is maintained by a dynamic balance between neuronal apoptosis and neurogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- In vitro induction effect of 1,25(OH)Biomedical journal · 2017Article
- Hair follicle-associated-pluripotent (HAP) stem cells.Cell cycle (Georgetown, Tex.) · 2017Review
- Engineering of Adult Neurogenesis and Gliogenesis.Cold Spring Harbor perspectives in biology · 2016Review
- Aging hair follicles rejuvenated by transplantation to a young subcutaneous environment.Cell cycle (Georgetown, Tex.) · 2016Article
- Stem Cells in Skin Regeneration, Wound Healing, and Their Clinical Applications.International journal of molecular sciences · 2015Review
- Viral and transgenic reporters and genetic analysis of adult neurogenesis.Cold Spring Harbor perspectives in biology · 2015Review
- Hair follicle stem cells: In vitro and in vivo neural differentiation.World journal of stem cells · 2015Review
- In vitro neural differentiation of CD34 (+) stem cell populations in hair follicles by three different neural induction protocols.In vitro cellular & developmental biology. Animal · 2015Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
The bulge region of the hair follicle serves as a repository for epithelial stem cells that can regenerate the follicle in each hair growth cycle and contribute to epidermis regeneration upon injury. Here we describe a population of multipotential stem cells in the hair follicle bulge region; these cells can be identified by fluorescence in transgenic nestin-GFP mice. The morphological features of these cells suggest that they maintain close associations with each other and with the surrounding niche. Upon explantation, these cells can give rise to neurosphere-like structures in vitro. When these cells are permitted to differentiate, they produce several cell types, including cells with neuronal, astrocytic, oligodendrocytic, smooth muscle, adipocytic, and other phenotypes. Furthermore, upon implantation into the developing nervous system of chick, these cells generate neuronal cells in vivo. We used transcriptional profiling to assess the relationship between these cells and embryonic and postnatal neural stem cells and to compare them with other stem cell populations of the bulge. Our results show that nestin-expressing cells in the bulge region of the hair follicle have stem cell-like properties, are multipotent, and can effectively generate cells of neural lineage in vitro and in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.