ReviewStem cell reviews2007
Prospective isolation and functional analysis of stem and differentiated cells from the mouse mammary gland.
Review in Stem cell reviews, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Terminal differentiation and anti-tumorigenic effects of prolactin in breast cancer.Frontiers in endocrinology · 2022Review
- Integrating single-cell RNA-sequencing and functional assays to decipher mammary cell states and lineage hierarchies.NPJ breast cancer · 2020Review
- Loss of E-Cadherin-Dependent Cell-Cell Adhesion and the Development and Progression of Cancer.Cold Spring Harbor perspectives in biology · 2018Review
- Multipotent Myoepithelial Progenitor Cells Are Born Early during Airway Submucosal Gland Development.American journal of respiratory cell and molecular biology · 2017Article
- Expanding Sca-1(+) mammary stem cell in the presence of oestrogen and growth hormone.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2012Article
- Isolation and characterization of progenitor cells in uninjured, adult rat lacrimal gland.Investigative ophthalmology & visual science · 2012Article
- RARα1 control of mammary gland ductal morphogenesis and wnt1-tumorigenesis.Breast cancer research : BCR · 2010Article
- Introduction: the myoepithelial cell and milk letdown; entrance to the multifunctional role of oxytocin.Journal of mammary gland biology and neoplasia · 2009Article
- Radiation resistance of breast cancer stem cells: understanding the clinical framework.Journal of mammary gland biology and neoplasia · 2009Review
- Transcriptome analysis of mammary epithelial subpopulations identifies novel determinants of lineage commitment and cell fate.BMC genomics · 2008Article
- Cancer stem cells in breast: current opinion and future challenges.Pathobiology : journal of immunopathology, molecular and cellular biology · 2008Review
- The controversial clinicobiological role of breast cancer stem cells.Journal of oncology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Prospective isolation and in vitro and in vivo analysis of primary mouse mammary epithelial cells has been used to separate cell subpopulations and identify stem, progenitor and differentiated cell compartments. Progress has been made from cell separation strategies based on a single marker of the luminal epithelial or myoepithelial compartments to use of markers that allow simultaneous isolation of non-epithelial, basal/myoepithelial and luminal epithelial cells. Transplant analysis has shown that mammary stem cells are found in the basal/myoepithelial compartment, whereas in vitro colony progenitors are found in the luminal compartment. A basal population enriched for stem cell activity can be purified from the myoepithelial cells and the most recent data shows that the luminal population can now be prospectively split into estrogen receptor positive and estrogen receptor negative cells. Future work aims to molecularly characterise these populations to identify new drug targets, which can be used to specifically kill breast cancer stem cells.
Indexed as
Identifiers
17873345What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.