ArticleEndocrine2007
Fat storage is partially dependent on vagal activity and insulin secretion of hypothalamic obese rat.
Article in Endocrine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 81 citations in OpenAlex.
- Vagus nerve stimulation increases energy expenditure: relation to brown adipose tissue activity.PloS one · 2013Trial
- Oral Copaiba Oil-Resin Supplementation Reduces Plasma and Hepatic Oxidative Stress in Female and Male Hypothalamic-Obese Animals.Food science & nutrition · 2026Article
- Vagal Splenic-Dependent Effects Influence Glucose Homeostasis, Insulin Secretion, and Histopathology of the Endocrine Pancreas in Hypothalamic Obese Male Rats: Vagus Nerve and Spleen Interactions Affect the Endocrine Pancreas.TheScientificWorldJournal · 2025Article
- GLP-1 Increases Circulating Leptin Levels in Truncal Vagotomized Rats.Biomedicines · 2023Article
- Ethyl Acetate Fraction and Isolated Phenolics Derivatives fromPharmaceutics · 2021Article
- The Vagus Nerve and Spleen: Influence on White Adipose Mass and Histology of Obese and Non-obese Rats.Frontiers in physiology · 2021Article
- Vagotomy associated with splenectomy reduces lipid accumulation and causes kidneys histological changes in rats with hypothalamic obesity.Acta cirurgica brasileira · 2021Article
- Metformin Improves Autonomic Nervous System Imbalance and Metabolic Dysfunction in Monosodium L-Glutamate-Treated Rats.Frontiers in endocrinology · 2021Article
- Taurine supplementation prevents endothelial dysfunction and attenuates structural changes in aortas from hypothalamic obese rats.European journal of nutrition · 2019Article
- Article
- Glibenclamide treatment blocks metabolic dysfunctions and improves vagal activity in monosodium glutamate-obese male rats.Endocrine · 2017Article
- Taurine supplementation regulates Iκ-Bα protein expression in adipose tissue and serum IL-4 and TNF-α concentrations in MSG obesity.European journal of nutrition · 2017Article
- Alteration of FXR phosphorylation and sumoylation in liver in the development of adult catch-up growth.Experimental biology and medicine (Maywood, N.J.) · 2017Article
- Vagotomy diminishes obesity in cafeteria rats by decreasing cholinergic potentiation of insulin release.Journal of physiology and biochemistry · 2016Article
- Adipose Tissue and Energy Expenditure: Central and Peripheral Neural Activation Pathways.Current obesity reports · 2016Review
- Vagotomy ameliorates islet morphofunction and body metabolic homeostasis in MSG-obese rats.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2015Article
- Duodenal-jejunal bypass restores insulin action and βeta-cell function in hypothalamic-obese rats.Obesity surgery · 2015Article
- Oral Metformin Treatment Counteracts Adipoinsular Axis Dysfunction in Hypothalamic Obese Rats.International scholarly research notices · 2015Article
- Impaired muscarinic type 3 (M3) receptor/PKC and PKA pathways in islets from MSG-obese rats.Molecular biology reports · 2013Article
- Impaired sympathoadrenal axis function contributes to enhanced insulin secretion in prediabetic obese rats.Experimental diabetes research · 2011Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypothalamic MSG-obese rats show hyperinsulinemia and tissue insulin resistance, and they display intense parasympathetic activity. Current analysis investigates whether early subdiaphragmatic vagotomy prevents tissue insulin sensitivity impairment in adult obese MSG-rats. Hypothalamic obesity was induced by MSG (4 mg/g BW), daily, from birth up to 5 days. Control animals receiving saline solution. On the 30th day rats underwent bilateral subdiaphragmatic vagotomy or sham surgery. An intravenous glucose tolerance test (i.v.GTT) was performed when rats turned 90 days old. Total white fat tissue (WAT) from rat carcass was extracted and isolated; the interscapular brown fat tissue (IBAT) was weighed. Rather than blocking obesity, vagotomy reduced WAT and IBAT in MSG-obese rats when the latter were compared to sham MSG-rats. High blood fasting insulin and normal glucose levels were also observed in MSG-obese rats. Although glucose intolerance, high insulin secretion, and significant insulin resistance were recorded, vagotomy improved fasting insulinemia, glucose tolerance and insulin tissue sensitivity in MSG-obese rats. Results suggest that increased fat accumulation is caused, at least in part, by high blood insulin concentration, and enhanced parasympathetic activity on MSG-obese rats.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.