ArticleThe Plant cell2007
INCURVATA2 encodes the catalytic subunit of DNA Polymerase alpha and interacts with genes involved in chromatin-mediated cellular memory in Arabidopsis thaliana.
Article in The Plant cell, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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Who cites it
59 citing papers in PubMed, 141 citations in OpenAlex.
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- Dissecting the genetic architecture of flag leaf morphology in Sichuan Wheat Germplasm using genome-wide association study.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Light and Shadows: Insights from Large-Scale Visual Screens for Arabidopsis Leaf Morphology Mutants.International journal of molecular sciences · 2025Review
- The emerging role of SARS-CoV-2 nonstructural protein 1 (nsp1) in epigenetic regulation of host gene expression.FEMS microbiology reviews · 2024Review
- The unequal functional redundancy of ArabidopsisFrontiers in plant science · 2023Article
- A splice site mutation in theHorticulture research · 2023Article
- A Mutation in DNA Polymerase α RescuesInternational journal of molecular sciences · 2021Article
- Mitotic Inheritance of PRC2-Mediated Silencing: Mechanistic Insights and Developmental Perspectives.Frontiers in plant science · 2020Review
- Plant DNA Polymerases.International journal of molecular sciences · 2019Review
- Phytohormone and Chromatin Crosstalk: The Missing Link For Developmental Plasticity?Frontiers in plant science · 2019Article
- Transcriptomics Identifies Modules of Differentially Expressed Genes and Novel Cyclotides inFrontiers in plant science · 2019Article
- Article
- Affinity proteomics reveals extensive phosphorylation of the Brassica chromosome axis protein ASY1 and a network of associated proteins at prophase I of meiosis.The Plant journal : for cell and molecular biology · 2018Article
- A genetic link between epigenetic repressor AS1-AS2 and DNA replication factors in establishment of adaxial-abaxial leaf polarity ofPlant biotechnology (Tokyo, Japan) · 2018Article
- Regulation of Plant Growth and Development: A Review From a Chromatin Remodeling Perspective.Frontiers in plant science · 2018Review
- PWWP-DOMAIN INTERACTOR OF POLYCOMBS1 Interacts with Polycomb-Group Proteins and Histones and Regulates Arabidopsis Flowering and Development.The Plant cell · 2018Article
- Suitability of two distinct approaches for the high-throughput study of the post-embryonic effects of embryo-lethal mutations in Arabidopsis.Scientific reports · 2017Article
- Emerging roles of chromatin in the maintenance of genome organization and function in plants.Genome biology · 2017Review
- Ctf4-related protein recruits LHP1-PRC2 to maintain H3K27me3 levels in dividing cells inProceedings of the National Academy of Sciences of the United States of America · 2017Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cell type-specific gene expression patterns are maintained by the stable inheritance of transcriptional states through mitosis, requiring the action of multiprotein complexes that remodel chromatin structure. Genetic and molecular interactions between chromatin remodeling factors and components of the DNA replication machinery have been identified in Schizosaccharomyces pombe, indicating that some epigenetic marks are replicated simultaneously to DNA with the participation of the DNA replication complexes. This model of epigenetic inheritance might be extended to the plant kingdom, as we report here with the positional cloning and characterization of INCURVATA2 (ICU2), which encodes the putative catalytic subunit of the DNA polymerase alpha of Arabidopsis thaliana. The strong icu2-2 and icu2-3 insertional alleles caused fully penetrant zygotic lethality when homozygous and incompletely penetrant gametophytic lethality, probably because of loss of DNA polymerase activity. The weak icu2-1 allele carried a point mutation and caused early flowering, leaf incurvature, and homeotic transformations of sepals into carpels and of petals into stamens. Further genetic analyses indicated that ICU2 interacts with TERMINAL FLOWER2, the ortholog of HETEROCHROMATIN PROTEIN1 of animals and yeasts, and with the Polycomb group (PcG) gene CURLY LEAF. Another PcG gene, EMBRYONIC FLOWER2, was found to be epistatic to ICU2. Quantitative RT-PCR analyses indicated that a number of regulatory genes were derepressed in the icu2-1 mutant, including genes associated with flowering time, floral meristem, and floral organ identity.
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