ArticlePlant physiology2007
Transcription factor RAP2.2 and its interacting partner SINAT2: stable elements in the carotenogenesis of Arabidopsis leaves.
Article in Plant physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 124 papers, 1 of them a synthesis that pooled it.
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Who cites it
124 citing papers in PubMed, 1 synthesis or guideline pooled it.
- In silico analysis of the Seven IN Absentia (SINA) genes in bread wheat sheds light on their structure in plants.PloS one · 2023Pooled it
- Genome-wide identification and evolutionary analysis of the ERF-VII gene family in the tea plant (Camellia sinensis) and functional characterization of CsRAP2.2 in response to cold stress.Plant cell reports · 2026Article
- SWI/SNF-type complexes-transcription factor interplay: a key regulatory interaction.Cellular & molecular biology letters · 2025Review
- ACT2.6: Global Gene Coexpression Network inGenes · 2025Article
- Ethylene response factor SlERF.D6 promotes ripening in part through transcription factors SlDEAR2 and SlTCP12.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Transcriptome reveals differential expression of flavor and color in closely related strains of tomato (PeerJ · 2025Article
- Identifying molecular targets for modulating carotenoid accumulation in rice grains.Biochemistry and biophysics reports · 2024Article
- Genome-Wide Analysis of Fruit Color and Carotenoid Content inPlants (Basel, Switzerland) · 2024Article
- Genome-wide analysis of AP2/ERF transcription factors that regulate fruit development of Chinese prickly ash.BMC plant biology · 2024Article
- RNA-seq-based comparative transcriptome analysis reveals the role ofHorticulture research · 2024Article
- The AP2/ERF Transcription Factor PgERF120 Regulates Ginsenoside Biosynthesis in Ginseng.Biomolecules · 2024Article
- Integrated Metabolomic and Transcriptomic Profiles Provide Insights into the Mechanisms of Anthocyanin and Carotenoid Biosynthesis in Petals ofPlants (Basel, Switzerland) · 2024Article
- 15-Foods (Basel, Switzerland) · 2024Article
- Effects of different light intensity on leaf color changes in a Chinese cabbage yellow cotyledon mutant.Frontiers in plant science · 2024Article
- Integrative Metabolome and Transcriptome Analyses Provide Insights into Carotenoid Variation in Different-Colored Peppers.International journal of molecular sciences · 2023Article
- Physiological Changes and Transcriptomic Analysis throughout On-Tree Fruit Ripening Process in Persimmon (Plants (Basel, Switzerland) · 2023Article
- ERFVII action and modulation through oxygen-sensing in Arabidopsis thaliana.Nature communications · 2023Article
- Transcriptomics and Metabolomics Reveal the Critical Genes of Carotenoid Biosynthesis and Color Formation of Goji (Plants (Basel, Switzerland) · 2023Article
- Advances of Apetala2/Ethylene Response Factors in Regulating Development and Stress Response in Maize.International journal of molecular sciences · 2023Review
- Genetic mapping of a single nuclear locus determines the white flesh color in watermelon (Frontiers in plant science · 2023Article
64 more citing papers are in PubMed but not listed here.
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5 authors.
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Abstract
The promoter of phytoene synthase, the first specific enzyme of carotenoid biosynthesis, shows two main regulatory regions: a G-box-containing region located near the TATA box, and a TATA box distal region containing the cis-acting element ATCTA, which mediates strong basal promoter activity. This second element was also present in the promoter of phytoene desaturase, the next step of the carotenoid pathway, suggesting a common regulatory mechanism. In this work, we demonstrate that AtRAP2.2, a member of the APETALA2 (AP2)/ethylene-responsive element-binding protein transcription factor family, binds to the ATCTA element. In Arabidopsis (Arabidopsis thaliana) leaves, AtRAP2.2 transcript and protein levels were tightly controlled as indicated by unchanged transcript and protein levels in T-DNA insertion mutants in the AtRAP2.2 promoter and 5' untranslated region and the lack of change in AtRAP2.2 protein levels in lines strongly overexpressing the AtRAP2.2 transcript. Homozygous loss-of-function mutants could not be obtained for the AtRAP2.2 5' untranslated region T-DNA insertion line indicating a lethal phenotype. In AtRAP2.2 overexpression lines, modest changes in phytoene synthase and phytoene desaturase transcripts were only observed in root-derived calli, which consequently showed a reduction in carotenoid content. The RING finger protein SEVEN IN ABSENTIA OF ARABIDOPSIS2 (SINAT2) was identified as an AtRAP2.2 interaction partner using a two-hybrid approach. The structure of SINAT2 and related proteins of Arabidopsis show homology to the SEVEN IN ABSENTIA protein of Drosophila that is involved in proteasome-mediated regulation in a variety of developmental processes. The action of SINAT2 may explain the recalcitrance of AtRAP2.2 protein levels to change by altering AtRAP2.2 transcription.
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