ArticleJournal of bacteriology2007
Flagella facilitate escape of Salmonella from oncotic macrophages.
Article in Journal of bacteriology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 52 citations in OpenAlex.
- Programmable Bacteria with Dynamic Virulence Modulation System for Precision Antitumor Immunity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Salmonellosis: An Overview of Epidemiology, Pathogenesis, and Innovative Approaches to Mitigate the Antimicrobial Resistant Infections.Antibiotics (Basel, Switzerland) · 2024Review
- Macrophage-mediated tumor-targeted delivery of engineeredActa pharmaceutica Sinica. B · 2022Article
- The Loss ofMicroorganisms · 2022Article
- The Small RNA RyhB Homologs fromMicroorganisms · 2021Article
- Type 1 interferon-dependent repression of NLRC4 and iPLA2 licenses down-regulation ofProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Detecting Salmonella Type II flagella production by transmission electron microscopy and immunocytochemistry.Journal of microbiology (Seoul, Korea) · 2020Article
- Dual RNA-Seq Unveils the Role of the Pseudomonas plecoglossicidaMicroorganisms · 2019Article
- The Small RNA PinT Contributes to PhoP-Mediated Regulation of theJournal of bacteriology · 2019Article
- Metatranscriptomic Analysis of the Bacterial SymbiontLife (Basel, Switzerland) · 2019Article
- Harnessing Macrophages for Controlled-Release Drug Delivery: Lessons From Microbes.Frontiers in pharmacology · 2019Review
- Neutrophil extracellular traps in immunity and disease.Nature reviews. Immunology · 2018Review
- Inorganic Polyphosphate Is Essential forFrontiers in cellular and infection microbiology · 2018Article
- AProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Trapping and viability of swimming bacteria in an optoelectric trap.Lab on a chip · 2016Article
- Article
- Macrophage cell death upon intracellular bacterial infection.Macrophage · 2015Article
- Evaluation of the live vaccine efficacy of virulence plasmid-cured, and phoP- or aroA-deficient Salmonella enterica serovar Typhimurium in mice.The Journal of veterinary medical science · 2015Article
- The Salmonella Spi1 virulence regulatory protein HilD directly activates transcription of the flagellar master operon flhDC.Journal of bacteriology · 2014Article
- Brucella dissociation is essential for macrophage egress and bacterial dissemination.Frontiers in cellular and infection microbiology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The intracellular parasite Salmonella enterica serovar Typhimurium causes a typhoid-like systemic disease in mice. Whereas the survival of Salmonella in phagocytes is well understood, little has been documented about the exit of intracellular Salmonella from host cells. Here we report that in a population of infected macrophages Salmonella induces "oncosis," an irreversible progression to eukaryotic cell death characterized by swelling of the entire cell body. Oncotic macrophages (OnMphis) are terminal deoxynucleotidyltransferase-mediated dUTP-biotin nick end labeling negative and lack actin filaments (F-actin). The plasma membrane of OnMphis filled with bacilli remains impermeable, and intracellular Salmonella bacilli move vigorously using flagella. Eventually, intracellular Salmonella bacilli intermittently exit host cells in a flagellum-dependent manner. These results suggest that induction of macrophage oncosis and intracellular accumulation of flagellated bacilli constitute a strategy whereby Salmonella escapes from host macrophages.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.