ArticleJournal of bacteriology2007
Role for the RecBCD recombination pathway for pilE gene variation in repair-proficient Neisseria gonorrhoeae.
Article in Journal of bacteriology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 17 citations in OpenAlex.
- A Double-Strand Break Does Not Promote Neisseria gonorrhoeae Pilin Antigenic Variation.Journal of bacteriology · 2019Article
- Analyzing Neisseria gonorrhoeae Pilin Antigenic Variation Using 454 Sequencing Technology.Journal of bacteriology · 2016Article
- H-NS suppresses pilE intragenic transcription and antigenic variation in Neisseria gonorrhoeae.Microbiology (Reading, England) · 2016Article
- Mobile DNA in the pathogenicMicrobiology spectrum · 2015Article
- Microbial antigenic variation mediated by homologous DNA recombination.FEMS microbiology reviews · 2012Review
- Coordinated phenotype switching with large-scale chromosome flip-flop inversion observed in bacteria.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Focusing homologous recombination: pilin antigenic variation in the pathogenic Neisseria.Molecular microbiology · 2011Review
- Organization of the electron transfer chain to oxygen in the obligate human pathogen Neisseria gonorrhoeae: roles for cytochromes c4 and c5, but not cytochrome c2, in oxygen reduction.Journal of bacteriology · 2010Article
- Spontaneous excision of the Salmonella enterica serovar Enteritidis-specific defective prophage-like element phiSE14.Journal of bacteriology · 2010Article
- Pilin antigenic variation occurs independently of the RecBCD pathway in Neisseria gonorrhoeae.Journal of bacteriology · 2009Article
- Pilin gene variation in Neisseria gonorrhoeae: reassessing the old paradigms.FEMS microbiology reviews · 2009Review
- Helicobacter pylori AddAB helicase-nuclease and RecA promote recombination-related DNA repair and survival during stomach colonization.Molecular microbiology · 2008Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of the RecBCD recombination pathway in PilE antigenic variation in Neisseria gonorrhoeae is contentious and appears to be strain dependent. In this study, N. gonorrhoeae strain MS11 recB mutants were assessed for recombination/repair. MS11 recB mutants were found to be highly susceptible to DNA treatments that caused double-chain breaks and were severely impaired for growth; recB growth suppressor mutants arose at high frequencies. When the recombination/repair capacity of strain MS11 was compared to that of strains FA1090 and P9, innate differences were observed between the strains, with FA1090 and P9 rec(+) bacteria presenting pronounced recombination/repair defects. Consequently, MS11 recB mutants present a more robust phenotype than the other strains that were tested. In addition, MS11 recB mutants are also shown to be defective for pilE/pilS recombination. Moreover, pilE/pilS recombination is shown to proceed with gonococci that carry inverted pilE loci. Consequently, a novel RecBCD-mediated double-chain-break repair model for PilE antigenic variation is proposed.
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