ArticleJournal of bacteriology2007
Diminished LcrV secretion attenuates Yersinia pseudotuberculosis virulence.
Article in Journal of bacteriology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed.
- Unraveling the Pathogenetic Potential and Immune Crosstalk of Yersinia spp. in Inflammatory Bowel Disease.Journal of immunology research · 2026Review
- Article
- Genomic Epidemiology and Phenotyping Reveal on-Farm Persistence and Cold Adaptation of Raw Milk Outbreak-AssociatedFrontiers in microbiology · 2019Article
- YopN Is Required for Efficient Effector Translocation and Virulence in Yersinia pseudotuberculosis.Infection and immunity · 2018Article
- The Amino-Terminal Part of the Needle-Tip Translocator LcrV ofFrontiers in cellular and infection microbiology · 2016Article
- Translational regulation of Yersinia enterocolitica mRNA encoding a type III secretion substrate.The Journal of biological chemistry · 2013Article
- A translocator-specific export signal establishes the translocator-effector secretion hierarchy that is important for type III secretion system function.Molecular microbiology · 2012Article
- Impact of the N-terminal secretor domain on YopD translocator function in Yersinia pseudotuberculosis type III secretion.Journal of bacteriology · 2011Article
- Human anti-plague monoclonal antibodies protect mice from Yersinia pestis in a bubonic plague model.PloS one · 2010Article
- Identification and characterization of small-molecule inhibitors of Yop translocation in Yersinia pseudotuberculosis.Antimicrobial agents and chemotherapy · 2010Article
- Control of effector export by the Pseudomonas aeruginosa type III secretion proteins PcrG and PcrV.Molecular microbiology · 2010Article
- Amino acid and structural variability of Yersinia pestis LcrV protein.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2010Article
- Autoproteolysis of YscU of Yersinia pseudotuberculosis is important for regulation of expression and secretion of Yop proteins.Journal of bacteriology · 2009Article
- Yersinia enterocolitica type III secretion of YopR requires a structure in its mRNA.Molecular microbiology · 2008Article
- Impassable YscP substrates and their impact on the Yersinia enterocolitica type III secretion pathway.Journal of bacteriology · 2008Article
- YscU cleavage and the assembly of Yersinia type III secretion machine complexes.Molecular microbiology · 2008Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many gram-negative bacterial pathogenicity factors that function beyond the outer membrane are secreted via a contact-dependent type III secretion system. Two types of substrates are predestined for this mode of secretion, namely, antihost effectors that are translocated directly into target cells and the translocators required for targeting of the effectors across the host cell membrane. N-terminal secretion signals are important for recognition of the protein cargo by the type III secretion machinery. Even though such signals are known for several effectors, a consensus signal sequence is not obvious. One of the translocators, LcrV, has been attributed other functions in addition to its role in translocation. These functions include regulation, presumably via interaction with LcrG inside bacteria, and immunomodulation via interaction with Toll-like receptor 2. Here we wanted to address the significance of the specific targeting of LcrV to the exterior for its function in regulation, effector targeting, and virulence. The results, highlighting key N-terminal amino acids important for LcrV secretion, allowed us to dissect the role of LcrV in regulation from that in effector targeting/virulence. While only low levels of exported LcrV were required for in vitro effector translocation, as deduced by a cell infection assay, fully functional export of LcrV was found to be a prerequisite for its role in virulence in the systemic murine infection model.
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