ArticleBiophysical journal2008
Micro- and macrorheological properties of isotropically cross-linked actin networks.
Article in Biophysical journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 74 citations in OpenAlex.
- State-dependent energy conversion produces degenerate dissipation in active actomyosin networks.bioRxiv : the preprint server for biology · 2026Article
- Crosslinker identity and dynamics regulate F-actin network structure and mechanics.Frontiers in cell and developmental biology · 2026Article
- High-throughput Mucus Microrheology for Phenotyping and Disease Modeling.bioRxiv : the preprint server for biology · 2025Article
- Scale-dependent interactions enable emergent microrheological stress response of actin-vimentin composites.Soft matter · 2024Article
- Crowding alters F-actin secondary structure and hydration.Communications biology · 2023Article
- Varying crosslinking motifs drive the mesoscale mechanics of actin-microtubule composites.Scientific reports · 2019Article
- Triggered disassembly and reassembly of actin networks induces rigidity phase transitions.Soft matter · 2019Article
- Multiscale analysis of architecture, cell size and the cell cortex reveals cortical F-actin density and composition are major contributors to mechanical properties during convergent extension.Development (Cambridge, England) · 2018Article
- Emergent mechanics of actomyosin drive punctuated contractions and shape network morphology in the cell cortex.PLoS computational biology · 2018Article
- Nonlinear Actin Deformations Lead to Network Stiffening, Yielding, and Nonuniform Stress Propagation.Biophysical journal · 2017Article
- Reversibility and Viscoelastic Properties of Micropillar Supported and Oriented Magnesium Bundled F-Actin.PloS one · 2015Article
- Properties of intermediate filament networks assembled from keratin 8 and 18 in the presence of Mg²+.Biophysical journal · 2012Article
- Mechanical signaling through the cytoskeleton regulates cell proliferation by coordinated focal adhesion and Rho GTPase signaling.Journal of cell science · 2011Article
- Article
- Predicting bulk mechanical properties of cellularized collagen gels using multiphoton microscopy.Acta biomaterialia · 2010Article
- Characterization of particle translocation through mucin hydrogels.Biophysical journal · 2010Article
- Passive and active microrheology for cross-linked F-actin networks in vitro.Acta biomaterialia · 2010Article
- Structural and viscoelastic properties of actin networks formed by espin or pathologically relevant espin mutants.Chemphyschem : a European journal of chemical physics and physical chemistry · 2009Article
- Computational analysis of viscoelastic properties of crosslinked actin networks.PLoS computational biology · 2009Article
- Cytoskeletal polymer networks: viscoelastic properties are determined by the microscopic interaction potential of cross-links.Biophysical journal · 2009Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cells make use of semiflexible biopolymers such as actin or intermediate filaments to control their local viscoelastic response by dynamically adjusting the concentration and type of cross-linking molecules. The microstructure of the resulting networks mainly determines their mechanical properties. It remains an important challenge to relate structural transitions to both the molecular properties of the cross-linking molecules and the mechanical response of the network. This can be achieved best by well defined in vitro model systems in combination with microscopic techniques. Here, we show that with increasing concentrations of the cross-linker heavy meromyosin, a transition in the mechanical network response occurs. At low cross-linker densities the network elasticity is dominated by the entanglement length l(e) of the polymer, whereas at high heavy meromyosin densities the cross-linker distance l(c) determines the elastic behavior. Using microrheology the formation of heterogeneous networks is observed at low cross-linker concentrations. Micro- and macrorheology both report the same transition to a homogeneous cross-linked phase. This transition is set by a constant average cross-linker distance l(c) approximately 15 microm. Thus, the micro- and macromechanical properties of isotropically cross-linked in vitro actin networks are determined by only one intrinsic network parameter.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.