ArticleBiophysical journal2008
Approximate analytical time-dependent solutions to describe large-amplitude local calcium transients in the presence of buffers.
Article in Biophysical journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Long-range diffusion of bound CaFrontiers in cellular neuroscience · 2026Article
- Bound CaFrontiers in physiology · 2023Article
- Rethinking calcium profiles around single channels: the exponential and periodic calcium nanodomains.Scientific reports · 2019Article
- Article
- Calmodulin and calmodulin kinase II mediate emergent bursting activity in the brainstem respiratory network (preBötzinger complex).The Journal of physiology · 2013Article
- Intracellular signaling by diffusion: can waves of hydrogen peroxide transmit intracellular information in plant cells?Frontiers in plant science · 2012Article
- Imaging cytoplasmic cAMP in mouse brainstem neurons.BMC neuroscience · 2009Article
- Metabotropic glutamate receptors activate dendritic calcium waves and TRPM channels which drive rhythmic respiratory patterns in mice.The Journal of physiology · 2008Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Local Ca(2+) signaling controls many neuronal functions, which is often achieved through spatial localization of Ca(2+) signals. These nanodomains are formed due to combined effects of Ca(2+) diffusion and binding to the cytoplasmic buffers. In this article we derived simple analytical expressions to describe Ca(2+) diffusion in the presence of mobile and immobile buffers. A nonlinear character of the reaction-diffusion problem was circumvented by introducing a logarithmic approximation of the concentration term. The obtained formulas reproduce free Ca(2+) levels up to 50 microM and their changes in the millisecond range. Derived equations can be useful to predict spatiotemporal profiles of large-amplitude [Ca(2+)] transients, which participate in various physiological processes.
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