Pregabalin decreases visceral pain and prevents spinal neuronal activation in rats.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

1. Systematic review of modulators of benzodiazepine receptors in irritable bowel syndrome: is there hope?World journal of gastroenterology · 2011
   Pooled it
2. Pilot trial: pregabalin on colonic sensorimotor functions in irritable bowel syndrome.Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver · 2014
   Trial
3. Effect of the α2δ ligand, pregabalin, on colonic sensory and motor functions in healthy adults.American journal of physiology. Gastrointestinal and liver physiology · 2011
   Trial
4. Targeting γ-aminobutyric acid pathways in irritable bowel syndrome: bridging central nervous system, enteric dysfunction, and the microbiota-gut-brain axis.Frontiers in pharmacology · 2025
   Review
5. Comparative effects of α2δ-1 ligands in mouse models of colonic hypersensitivity.World journal of gastroenterology · 2016
   Article
6. Stress-induced visceral pain: toward animal models of irritable-bowel syndrome and associated comorbidities.Frontiers in psychiatry · 2015
   Review
7. The use of non-narcotic pain medication in pediatric gastroenterology.Paediatric drugs · 2014
   Review
8. The newly developed CRF1-receptor antagonists, NGD 98-2 and NGD 9002, suppress acute stress-induced stimulation of colonic motor function and visceral hypersensitivity in rats.PloS one · 2013
   Article
9. Stress and visceral pain: from animal models to clinical therapies.Experimental neurology · 2012
   Review
10. Drug management of visceral pain: concepts from basic research.Pain research and treatment · 2012
    Article
11. Pregabalin modulation of spinal and brainstem visceral nociceptive processing.Pain · 2011
    Article
12. Stress-related alterations of visceral sensation: animal models for irritable bowel syndrome study.Journal of neurogastroenterology and motility · 2011
    Article
13. Pregabalin suppresses spinal neuronal hyperexcitability and visceral hypersensitivity in the absence of peripheral pathophysiology.Anesthesiology · 2011
    Article
14. Pregabalin as a neuroprotector after spinal cord injury in rats: biochemical analysis and effect on glial cells.Journal of Korean medical science · 2011
    Article
15. Alpha 2 Delta (α(2)δ) Ligands, Gabapentin and Pregabalin: What is the Evidence for Potential Use of These Ligands in Irritable Bowel Syndrome.Frontiers in pharmacology · 2011
    Article
16. Effects of pregabalin on visceral pain responses and colonic compliance in rats.British journal of pharmacology · 2008
    Article

Corrections and comments

• Comment on
  Effect of a second-generation alpha2delta ligand (pregabalin) on visceral sensation in hypersensitive patients with irritable bowel syndrome.2007

Authors and funding

6 authors at 2 institutions in 1 country.

Funding

Abstract

PubMed holds no abstract for this paper.

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