ArticleAmerican journal of respiratory cell and molecular biology2008
Effects of KGF on alveolar epithelial cell transdifferentiation are mediated by JNK signaling.
Article in American journal of respiratory cell and molecular biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 42 citations in OpenAlex.
- CD45/CD11b positive subsets of adult lung anchorage-independent cells harness epithelial stem cells in culture.Journal of tissue engineering and regenerative medicine · 2013Trial
- Review
- Generation of human alveolar epithelial type I cells from pluripotent stem cells.Cell stem cell · 2024Article
- Development of an in vitro human alveolar epithelial air-liquid interface model using a small molecule inhibitor cocktail.BMC molecular and cell biology · 2024Article
- Characteristics of Passive Solute Transport across Primary Rat Alveolar Epithelial Cell Monolayers.Membranes · 2021Article
- Heterogeneous groups of alveolar type II cells in lung homeostasis and repair.American journal of physiology. Cell physiology · 2020Review
- Stem cells and lung regeneration.American journal of physiology. Cell physiology · 2020Review
- Effects of Different Ligands in the Notch Signaling Pathway on the Proliferation and Transdifferentiation of Primary Type II Alveolar Epithelial Cells.Frontiers in pediatrics · 2020Article
- Article
- Dlk1-Mediated Temporal Regulation of Notch Signaling Is Required for Differentiation of Alveolar Type II to Type I Cells during Repair.Cell reports · 2019Article
- IDH3 mediates apoptosis of alveolar epithelial cells type 2 due to mitochondrial CaCell death & disease · 2017Article
- Cross-Species Transcriptome Profiling Identifies New Alveolar Epithelial Type I Cell-Specific Genes.American journal of respiratory cell and molecular biology · 2017Article
- In vitro model alveoli from photodegradable microsphere templates.Biomaterials science · 2015Article
- Alveolar epithelium: beyond the barrier.American journal of respiratory cell and molecular biology · 2014Article
- Breaking the in vitro alveolar type II cell proliferation barrier while retaining ion transport properties.American journal of respiratory cell and molecular biology · 2014Article
- Article
- The effects of adenoviral transfection of the keratinocyte growth factor gene on epidermal stem cells: an in vitro study.Molecules and cells · 2013Article
- GDNF-independent ureteric budding: role of PI3K-independent activation of AKT and FOSB/JUN/AP-1 signaling.Biology open · 2013Article
- Contribution of CFTR to alveolar fluid clearance by lipoxin A4 via PI3K/Akt pathway in LPS-induced acute lung injury.Mediators of inflammation · 2013Article
- Keratinocyte growth factor improves alveolar barrier function: keeping claudins in line.American journal of physiology. Lung cellular and molecular physiology · 2010Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Rat alveolar epithelial cells (AEC) in primary culture transdifferentiate from a type II (AT2) toward a type I (AT1) cell-like phenotype, a process that can be both prevented and reversed by keratinocyte growth factor (KGF). Microarray analysis revealed that these effects of KGF are associated with up-regulation of key molecules in the mitogen-activated protein kinase (MAPK) pathway. To further explore the role of three key MAPK (i.e., extracellular signal-related kinase [ERK] 1/2, c-Jun N-terminal kinase [JNK] and p38) in mediating effects of KGF on AEC phenotype, primary rat AEC cultivated in minimal defined serum-free medium (MDSF) were treated with KGF (10 ng/ml) from Day 4 for intervals up to 48 hours. Exposure to KGF activated all three MAPK, JNK, ERK1/2, and p38. Inhibition of JNK, but not of ERK1/2 or p38, abrogated the ability of KGF to maintain the AT2 cell phenotype, as evidenced by loss of expression of lamellar membrane protein (p180) and increased reactivity with the AT1 cell-specific monoclonal antibody VIIIB2 by Day 6 in culture. Overexpression of JNKK2, upstream kinase of JNK, increased activation of endogenous c-Jun in association with increased expression of p180 and abrogation of AQP5, suggesting that activation of c-Jun promotes retention of the AT2 cell phenotype. These results indicate that retention of the AT2 cell phenotype by KGF involves c-Jun and suggest that activation of c-Jun kinase may be an important determinant of maintenance of AT2 cell phenotype.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.