ReviewCurrent opinion in pharmacology2007
Plasmon-waveguide resonance (PWR) spectroscopy for directly viewing rates of GPCR/G-protein interactions and quantifying affinities.
Review in Current opinion in pharmacology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- Label-Free Plasmon-Waveguide Resonance Analysis of Mucin Network Remodeling by Cationic Polymers.ACS measurement science au · 2026Article
- Development of an EPR-based methodology to study protein-lipid interaction.Biophysical chemistry · 2026Article
- Improved Detection of Plasmon Waveguide Resonance Using Diverging Beam, Liquid Crystal Retarder, and Application to Lipid Orientation Determination.Sensors (Basel, Switzerland) · 2019Article
- Origin and prediction of free-solution interaction studies performed label-free.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Towards structural systems pharmacology to study complex diseases and personalized medicine.PLoS computational biology · 2014Review
- Signalling bias in new drug discovery: detection, quantification and therapeutic impact.Nature reviews. Drug discovery · 2013Review
- New concepts in pharmacological efficacy at 7TM receptors: IUPHAR review 2.British journal of pharmacology · 2013Review
- The potential for selective pharmacological therapies through biased receptor signaling.BMC pharmacology & toxicology · 2012Review
- The significance of G protein-coupled receptor crystallography for drug discovery.Pharmacological reviews · 2011Review
- Sensitivity Comparison of Surface Plasmon Resonance and Plasmon-Waveguide Resonance Biosensors.Sensors and actuators. B, Chemical · 2011Article
- Role of membrane integrity on G protein-coupled receptors: Rhodopsin stability and function.Progress in lipid research · 2011Review
- Seven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery.Pharmacological reviews · 2010Review
- Biased agonism.F1000 biology reports · 2009Article
- Cellular assays as portals to seven-transmembrane receptor-based drug discovery.Nature reviews. Drug discovery · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Plasmon-waveguide resonance (PWR) spectroscopy is an optical technique that has been developed in our laboratories and applied to the study of membrane-associated proteins, especially GPCRs. It has high sensitivity and requires no labeling of materials, and it can monitor changes in proteolipid mass density and conformation in real time using plasmon excitation by light polarized both perpendicular and parallel to the resonator surface. Direct measurements will be described of the association of ligands and G-proteins to GPCRs incorporated into a self-assembled lipid bilayer deposited on the silica surface of a PWR resonator. These studies have provided new insights into the functioning of this important class of signaling proteins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.