ReviewRespiratory physiology & neurobiology2008
Pharyngeal motor control and the pathogenesis of obstructive sleep apnea.
Review in Respiratory physiology & neurobiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it, 138 citations in OpenAlex.
- The impact of continuous positive airway pressure combined with lifestyle intervention on patients with obstructive sleep apnea: a multilevel meta-analysis.Frontiers in medicine · 2026Pooled it
- Desipramine Increases Genioglossus Activity and Reduces Upper Airway Collapsibility during Non-REM Sleep in Healthy Subjects.American journal of respiratory and critical care medicine · 2016Trial
- Comparison of craniofacial skeletal morphology in pediatric obstructive sleep apnea-hypopnea syndrome patients with class II and class III malocclusions: a retrospective cross-sectional study.Frontiers in pediatrics · 2026Article
- SAS-CARE-1 study: stroke topography and polysomnography-based respiratory sleep characteristics.Sleep & breathing = Schlaf & Atmung · 2025Article
- The Role of Mitochondria in Obstructive Sleep Apnea: Implications for the Upper Airway Muscles.International journal of molecular sciences · 2025Review
- Anesthesiologic Management of Adult and Pediatric Patients with Obstructive Sleep Apnea.Healthcare (Basel, Switzerland) · 2025Review
- Article
- Dental pulp stem cells promote genioglossus repair and systemic amelioration in chronic intermittent hypoxia.iScience · 2024Article
- The Effects of Obstructive Sleep Apnea on the Cardiovascular System: A Comprehensive Review.Journal of clinical medicine · 2024Review
- Cephalometric Screening Assessment for Superior Airway Space Narrowing-Added Value of Three-Dimensional Imaging.Journal of clinical medicine · 2024Article
- Article
- Drive versus Pressure Contributions to Genioglossus Activity in Obstructive Sleep Apnea.Annals of the American Thoracic Society · 2023Article
- 30-Day Postoperative Outcomes in Adults with Obstructive Sleep Apnea Undergoing Upper Airway Surgery.Journal of clinical medicine · 2022Article
- Hyoid bone position as an indicator of severe obstructive sleep apnea.BMC pulmonary medicine · 2022Article
- Implications of Obstructive Sleep-related Breathing Disorder in Dentistry: Focus on Snoring and Obstructive Sleep Apnea.Dental research and oral health · 2022Article
- Management of Obstructive Sleep Apnea in Patients With Heart Failure.Frontiers in medicine · 2022Review
- An introduction to artificial intelligence in sleep medicine.Journal of thoracic disease · 2021Article
- Gender Issues in Obstructive Sleep Apnea.The Yale journal of biology and medicine · 2021Review
- A review of therapies for the overlap syndrome of obstructive sleep apnea and chronic obstructive pulmonary disease.FASEB bioAdvances · 2021Article
- Impact of histaminergic H3 receptor antagonist on hypoglossal nucleus in chronic intermittent hypoxia conditions.Psychopharmacology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The upper airway in patients with obstructive sleep apnea (OSA) is thought to collapse during sleep at least in part, because of a sleep related reduction in upper airway dilator muscle activity. Therefore, a comprehensive understanding of the neural regulation of these muscles is warranted. The dilator muscles can be classified in two broad categories; those that have respiratory related activity and those that fire constantly throughout the respiratory cycle. The motor control of these two groups likely differs with the former receiving input from respiratory neurons and negative pressure reflex circuits. The activity of both muscle groups is reduced shortly after sleep onset, indicating that both receive input from brainstem neurons involved in sleep regulation. In the apnea patient, this may lead to pharyngeal airway collapse. This review briefly describes the currently proposed sleep and respiratory neural pathways and how these circuits interact with the upper airway dilator muscle motorneurones, including recent evidence from animal studies.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.