ArticleThe Journal of nutritional biochemistry2008
Influence of maternal undernutrition and overfeeding on cardiac ciliary neurotrophic factor receptor and ventricular size in fetal sheep.
Article in The Journal of nutritional biochemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 54 citations in OpenAlex.
- Insights from animal models: Dissecting the independent roles of oxygen and nutrients in the fetal origins of cardiovascular disease.The Journal of physiology · 2026Review
- Programming by maternal obesity: a pathway to poor cardiometabolic health in the offspring.The Proceedings of the Nutrition Society · 2022Review
- Effects of Maternal Nutrient Restriction and Melatonin Supplementation on Cardiomyocyte Cell Development Parameters Using Machine Learning Techniques.Animals : an open access journal from MDPI · 2022Article
- Cardiovascular consequences of maternal obesity throughout the lifespan in first generation sheep.PloS one · 2022Article
- Programming of Vascular Dysfunction by Maternal Stress: Immune System Implications.Frontiers in physiology · 2022Review
- Maternal Overnutrition During Gestation in Sheep Alters Autophagy Associated Pathways in Offspring Heart.Frontiers in genetics · 2021Article
- A Review of Maternal Nutrition during Pregnancy and Impact on the Offspring through Development: Evidence from Animal Models of Over- and Undernutrition.International journal of environmental research and public health · 2020Article
- Role of Dietary Amino Acids and Nutrient Sensing System in Pregnancy Associated Disorders.Frontiers in pharmacology · 2020Review
- Maternal obesity impairs fetal cardiomyocyte contractile function in sheep.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Gestational Hypoxia and Developmental Plasticity.Physiological reviews · 2018Review
- Fetal programming as a predictor of adult health or disease: the need to reevaluate fetal heart function.Heart failure reviews · 2017Review
- Endocrine and other physiologic modulators of perinatal cardiomyocyte endowment.The Journal of endocrinology · 2016Review
- Multigenerational impact of maternal overnutrition/obesity in the sheep on the neonatal leptin surge in granddaughters.International journal of obesity (2005) · 2015Article
- Maternal nutrient restriction during pregnancy impairs an endothelium-derived hyperpolarizing factor-like pathway in sheep fetal coronary arteries.American journal of physiology. Heart and circulatory physiology · 2014Article
- Influence of gestational overfeeding on myocardial proinflammatory mediators in fetal sheep heart.The Journal of nutritional biochemistry · 2013Article
- Identification and comparative analyses of myocardial miRNAs involved in the fetal response to maternal obesity.Physiological genomics · 2013Article
- Diet reduction to requirements in obese/overfed ewes from early gestation prevents glucose/insulin dysregulation and returns fetal adiposity and organ development to control levels.American journal of physiology. Endocrinology and metabolism · 2013Article
- Elevated glucocorticoids during ovine pregnancy increase appetite and produce glucose dysregulation and adiposity in their granddaughters in response to ad libitum feeding at 1 year of age.American journal of obstetrics and gynecology · 2013Article
- Multigenerational effects of fetal dexamethasone exposure on the hypothalamic-pituitary-adrenal axis of first- and second-generation female offspring.American journal of obstetrics and gynecology · 2013Article
- Role of the pre- and post-natal environment in developmental programming of health and productivity.Molecular and cellular endocrinology · 2012Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Intrauterine nutrition status is reported to correlate with risk of cardiovascular diseases in adulthood. Either under- or overnutrition during early to mid gestation contributes to altered fetal growth and ventricular geometry. This study was designed to examine myocardial expression of ciliary neurotrophic factor receptor alpha (CNTFRalpha) and its downstream mediator signal transducer and activator of transcription 3 (STAT3) on maternal undernutrition- or overnutrition-induced changes in fetal heart weight. Multiparous ewes were fed with 50% [nutrient-restricted (NR)], 100% (control) or 150% [overfed (OF)] of National Research Council requirements from 28 to 78 days of gestation (dG; term, 148 dG). Ewes were euthanized on Day 78, and the gravid uteri and fetuses recovered. Ventricular protein expression of CNTFRalpha, STAT3, phosphorylated STAT3, insulin-like growth factor I receptor (IGF-1R), and IGF binding protein 3 (IGFBP3) were quantitated using Western blot. Plasma cortisol levels were higher in both NR and OF fetuses, whereas plasma IGF-1 levels were lower and higher in NR and OF fetuses. Fetal weights were reduced by 29.9% in NR ewes and were increased by 22.2% in fetuses from OF ewes compared to control group. Nutrient restriction did not affect fetal heart or ventricular weights, whereas overfeeding increased heart and ventricular weights. Protein expression of CNTFRalpha in fetal ventricular tissue was reduced in OF group, whereas STAT3 and phosphorylated STAT3 levels were reduced in both NR and OF groups. Expression of IGF-1R and IGFBP3 was unaffected in either NR or OF group. These data suggested that, compared with maternal undernutrition, intrauterine overfeeding during early to mid gestation is associated with increases in fetal blood concentrations of cortisol and IGF-1, in association with ventricular hypertrophy where reduced expression of CNTFRalpha and STAT3 may play a role.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.